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| Citó,M.C.O.; Silva,M.I.G.; Santos,L.K.X.; Fernandes,M.L.; Melo,F.H.C.; Aguiar,J.A.C.; Lopes,I.S.; Sousa,P.B.; Vasconcelos,S.M.M.; Macêdo,D.S.; Sousa,F.C.F.. |
| Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hoodia gordonii; Antidepressant action; Monoaminergic system; Forced swimming test. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100057 |
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