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| Rigo,Flavia Karine; Rossato,Mateus Fortes; Borges,Vanessa; Silva,Juliana Figueira da; Pereira,Elizete Maria Rita; Ávila,Ricardo Andrez Machado de; Trevisan,Gabriela; Santos,Duana Carvalho dos; Diniz,Danuza Montijo; Silva,Marco Aurélio Romano; Castro Junior,Célio José de; Cunha,Thiago Mattar; Ferreira,Juliano; Gomez,Marcus Vinicius. |
| ABSTRACT Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this study aimed to investigate the possible antinociceptive effect of intravenous recombinant Phα1β in rat models of neuropathic pain, as well as its side effects on motor, cardiac (heart rate and blood pressure), and biochemical parameters. Methods: Male Wistar rats and male Balb-C mice were used in this study. Giotto Biotech® synthesized the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Recombinant Phα1β Analgesia Neuropathic pain Intravenous drug delivery system Side effects; Cardiac function; Motor activity; Biochemicals. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100309 |
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| Machado,J.A.; Ghizoni,M.F.; Bertelli,J.; Teske,Gabriel C.; Teske,Guilherme C.; Martins,D.F.; Mazzardo-Martins,L.; Cargnin-Ferreira,E.; Santos,A.R.S.; Piovezan,A.P.. |
| The rat models currently employed for studies of nerve regeneration present distinct disadvantages. We propose a new technique of stretch-induced nerve injury, used here to evaluate the influence of gabapentin (GBP) on nerve regeneration. Male Wistar rats (300 g; n=36) underwent surgery and exposure of the median nerve in the right forelimbs, either with or without nerve injury. The technique was performed using distal and proximal clamps separated by a distance of 2 cm and a sliding distance of 3 mm. The nerve was compressed and stretched for 5 s until the bands of Fontana disappeared. The animals were evaluated in relation to functional, biochemical and histological parameters. Stretching of the median nerve led to complete loss of motor function up to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nerve regeneration; Median nerve; Motor activity; Rat model. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100929 |
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