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| FONSECA,LEONARDO M.; GARCEZ,TATIANA C.; PENHA,LUCIANA; FREIRE-DE-LIMA,LEONARDO; MAES,EMMANUEL; COSTA,KELLI M.; MENDONÇA-PREVIATO,LUCIA; PREVIATO,JOSE O.. |
| ABSTRACT One of the main obstacles to the treatment of Chagas disease is the genetic and phenotypical variance displayed by T. cruzi strains, resulting in differences in morphology, virulence, pathogenicity and drug susceptibility. To better understand the role of glycoconjungates in Chagas disease, we performed the molecular characterization of the O-linked chains from mucins and glycoinositolphospholipids (GIPLs) of the Silvio X10 clone 1 strain. We demonstrated the presence of a β-galactofuranose (β-Galf) unity linked to the O-4 position of the α-N-acetylglucosamine (α-GlcNAc)O-4 in Tc-mucins. GIPLs analysis showed that the lipidic portion is exclusively composed of ceramide and the PI-oligossacharidic portion contains the Man4(AEP)GlcN-Ins-PO4 core,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: T. cruzi; Glycans; Mucins; Glycoinositolphospholipids.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401519 |
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