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Preparation of mupirocin-loaded polymeric nanocapsules using essential oil of rosemary BJPS
Rubenick,Jaqueline Bandeira; Rubim,Alexandre Machado; Bellé,Francieli; Nogueira-Librelotto,Daniele Rubert; Rolim,Clarice Madalena Bueno.
Abstract The purpose of this study was to prepare and characterize mupirocin-loaded polymeric nanocapsules using two different oils and to develop and validate an analytical method for quantitative determination by high performance liquid chromatography. The mean size of the nanoparticles was 233.05 nm and 275.03 nm for nanocapsules with a rosemary oil like oily core and caprylic/capric triglyceride, respectively, and a good polydispersity index below 0.25 for both formulations. The nanocapsules showed good stability when stored at 40 ºC and room temperature for 30 days. The quantitative method was performed with a mobile phase consisting of ammonium ammonium acetate (0.05 M adjusted to pH 5.0 with acetic acid) and acetonitrile 60:40 (v/v); the flow rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mupirocin/High Performance Liquid Chromatography; Mupirocin/Polymeric nanocapsules; Rosemary oil..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100623
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