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Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine International Journal of Morphology
Caiaffo,Vitor; Ribeiro,Alice Sá Carneiro; de Oliveira,Belisa Duarte Ribeiro; de Albuquerque,Yuri Mateus Lima; de Moraes,Silvia Regina Arruda.
The pharmacological manipulation with selective inhibitor of serotonin reuptake (SSRIs) can modify the operation of the serotonergic system and may facilitate or inhibit the action of this system, inducing changes in the morphology of the skeletal muscle of rats. The objective of this study was to evaluate the action of the treatment with fluoxetine during the critical period of the animal´s life on development of the soleus and lateral gastrocnemius muscles, under the aspects of weight, the number of nuclei of myocyte cells and cross-sectional area of muscle fibers. Twenty four (30 and 90-day-old) male Wistar rats were used. They were treated with saline solution (NaCl 0.9%; 1 ml/100 g of body weight) or fluoxetine (10 mg; 1 ml/100g of body weight). The...
Tipo: Journal article Palavras-chave: Fluoxetine; Muscles Fiber; Skeletal Muscle; Myonuclei; Cross Section Area.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300001
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