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Farnesol in combination with N-acetylcysteine against Staphylococcus epidermidis planktonic and biofilm cells BJM
Gomes,Fernanda; Leite,Bruna; Teixeira,Pilar; Azeredo,Joana; Oliveira,Rosário.
Staphylococcus epidermidis is the most frequent cause of nosocomial sepsis and catheter-related infections, in which biofilm formation is considered to be the main virulence mechanism. In biofilm environment, microbes exhibit enhanced resistance to antimicrobial agents. This fact boosted the search of possible alternatives to antibiotics. Farnesol and N-acetylcysteine (NAC) are non-antibiotic drugs that have demonstrated antibacterial properties. In this study, the effect of farnesol and NAC isolated or in combination (farnesol+NAC) was evaluated. NAC at 10 × MIC caused a total cell death in planktonic cells. On the other hand, S. epidermidis biofilms exhibited 4 log reduction in viable cell number after a 24h treatment with NAC at the former...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nosocomial infection; Biofilm; Staphylococci; Farnesol; N- acetylcysteine.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100026
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