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| Zhang,Jingmin; Wang,Yafeng; Peng,Youmei; Qin,Chongzhen; Liu,Yixian; Li,Jingjing; Jiang,Jinhua; Zhou,Yubing; Chang,Junbiao; Wang,Qingduan. |
| ABSTRACT Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of clinically resistant HBV strains is imperative, and new antiviral drugs are needed urgently to prevent selection of drug-resistant HBV mutants. A novel fluorinated cytidine analog, NCC (N-cyclopropyl-4′-azido-2′-deoxy-2′-fluoro-β-d-cytidine), was recently shown to strongly inhibit human HBV in vitro and in vivo. This study was designed to evaluate the antiviral activity of NCC against lamivudine-resistant HBV. We generated a stable cell line encoding the major pattern of lamivudine-resistant mutations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: N-cyclopropyl-4′-azido-2′-deoxy-2′-fluoro-β-D- cytidine; Hepatitis B virus; HepG2.RL1 cells; Lamivudine-resistant; RtL180M/M204V. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600477 |
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