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	Provedor de dados BJPS (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Batool,Maleeha Waqar and Sidra (1) Cruz,José Geraldo Pereira da (1) Cruz,Júlia Niehues da (1) Lima,Daniela Delwing de (1) Magro,Débora Delwing Dal (1) Palavra-chave N-methyl-D-aspartate (2) Alzheimer’s dieases (1) Antagonists (1) Anxiolytic effects (1) Conantokins (1) Docking (1) Glutamate (1) In silico (1) Membrane/lipid rafts (1) NR2B (1) Neurotransmitter (1) Simvastatin. (1) Synaptic plasticity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease J. Venom. Anim. Toxins incl. Trop. Dis. Batool,Maleeha Waqar and Sidra. Abstract Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory. The subunit N-methyl D-aspartate receptor subtype 2B (NR2B) is the chief excitatory neurotransmitter receptor in the mammalian brain. Disturbances in the neurotransmission mediated by the NMDA receptor are caused by its overexposure to glutamate neurotransmitter and can be treated by its binding to an antagonist. Among several antagonists, conantokins from cone snails are reported to bind to NMDA receptors. Methods This study was designed to analyze the binding mode of conantokins with NMDA receptors in both humans... Tipo: Info:eu-repo/semantics/article Palavras-chave: N-methyl-D-aspartate; Glutamate; Synaptic plasticity; NR2B; Neurotransmitter; Antagonists; Conantokins; Docking; In silico; Alzheimer’s dieases. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100317 Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review BJPS Cruz,Júlia Niehues da; Magro,Débora Delwing Dal; Lima,Daniela Delwing de; Cruz,José Geraldo Pereira da. ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor. Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiolytic effects; Membrane/lipid rafts; N-methyl-D-aspartate; Simvastatin.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100401 Registros recuperados: 2 Primeira ... 1 ... Última

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