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| CAMILO,Cicera J.; LEITE,Débora O. D.; SILVA,Angelo R. A. e; MENEZES,Irwin R. A.; COUTINHO,Henrique D. M.; COSTA,José G. M. da. |
| ABSTRACT Liposomes and niosomes are currently the most studied lipid vesicles in the nanomedicine field. The system formed by a phospholipid bilayer in aqueous medium allows these vesicles to carry both hydrophilic and lipophilic compounds, providing an increase in solubility of drugs already used in conventional therapy. The focus on the development of these vesicles should be directed to determining the ideal composition, with low toxicity, biocompatibility and which remains stable for long periods. These characteristics are related to the components used for formulation and the substances that will be encapsulated. Another important point relates to the methods used during formulation, which are important in determining the type of vesicle formed,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Components; Formulation; Liposomes; Nanomedicine; Niosomes. |
| Ano: 2020 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2020000200339 |
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| González-Nilo,Fernando; Pérez-Acle,Tomás; Guínez-Molinos,Sergio; Geraldo,Daniela A; Sandoval,Claudia; Yévenes,Alejandro; Santos,Leonardo S; Laurie,V. Felipe; Mendoza,Hegaly; Cachau,Raúl E. |
| After the progress made during the genomics era, bioinformatics was tasked with supporting the flow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and computational chemistry tools to store, standardize, analyze, and visualize nanobiotechnological information. Thus, old and new bioinformatic and computational chemistry tools have been merged into a new sub-discipline: nanoinformatics. This review takes a second look at the development of this new and exciting area as seen from the perspective of the evolution of nanobiotechnology applied to the life sciences. The knowledge obtained at the nano-scale level implies answers to new questions and the development of new concepts in different... |
| Tipo: Journal article |
Palavras-chave: Bioinformatics; Molecular simulation; Nanobiotechnology; Nanoinformatics; Nanomedicine. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100006 |
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| Caminade,Anne-Marie; Turrin,Cédric-Olivier; Majoral,Jean-Pierre. |
| Dendrimers are hyperbranched and perfectly defined macromolecules, constituted of branches emanating from a central core in an iterative fashion. Phosphorhydrazone dendrimers constitute a special family of dendrimers, possessing one phosphorus atom at each branching point. The internal structure of these dendrimers is hydrophobic, but hydrophilic terminal groups can induce the solubility of the whole structure in water. Indeed, the properties of these compounds are mainly driven by the type of terminal groups their bear; this is especially true for the biological properties. For instance, positively charged terminal groups are efficient for transfection experiments, as drug carriers, as anti-prion agents, and as inhibitor of the aggregation of Alzheimer's... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dendrimers; Phosphorhydrazone dendrimers; Biological properties; Nanomedicine. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700004 |
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| Adeyemi, Oluyomi Stephen; Murata, Yuho; Sugi, Tatsuki; Kato, Kentaro. |
| This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01-1,000 mu g/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of <= 7, <= 1, and <= 100 mu g/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a >= 20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results... |
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Palavras-chave: Antiparasite; Drug screening; Nanomedicine; Toxoplasmosis. |
| Ano: 2017 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4450 |
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