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| Miranda,Cíntia A SF; Cardoso,Maria G; Mansanares,Mariana E; Gomes,Marcos S; Marcussi,Silvana. |
| Background The search for new inhibitors of snake venom toxins is essential to complement or even replace traditional antivenom therapy, especially in relation to compounds that neutralize the local effects of envenomations. Besides their possible use as alternative to traditional antivenom therapy, some plant species possess bioactive secondary metabolites including essential oils, which can be extracted from weeds that are considered substantial problems for agriculture, such as Hedychium coronarium.Methods The essential oils of leaves and rhizomes from H. coronarium were extracted by hydrodistillation, and their potential inhibitory effects on the coagulant and fibrinogenolytic activities induced by the venoms of Lachesis muta,Bothrops atrox and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Volatile oils; Weeds; Natural inhibitors; Antivenom therapy. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200313 |
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| OLIVEIRA,CARLOS H.M.; SIMÃO,ANDERSON A.; TRENTO,MARCUS V.C.; CÉSAR,PEDRO H.S.; MARCUSSI,SILVANA. |
| ABSTRACT The enzyme inhibition by natural and/ or low-cost compounds may represent a valuable adjunct to traditional serotherapy performed in cases of snakebite, mainly with a view to mitigate the local effects of envenoming. The objective of this study was to evaluate possible interactions between vitamins and enzymes that comprise Bothrops atrox and Crotalus durissus terrificus venoms, in vitro. Proteolysis inhibition assays (substrates: azocasein, collagen, gelatin and fibrinogen), hemolysis, coagulation, hemagglutination were carried out using different proportions of vitamins in face of to inhibit minimum effective dose of each venom. The vitamins were responsible for reducing 100% of breaking azocasein by C.d.t. venom, thrombolysis induced by B.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiophidian properties; Antioxidants; Blood cells; Hemostatic processes; Natural inhibitors. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000502005 |
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