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| Registros recuperados: 48 | |
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| Oliveira,Ademir Kleber M; Rizzi,Elvia Silvia; Pereira,Kelly Cristina L; Bono,José Antônio M; Matias,José Carlos Pina; Rosemary. |
| ABSTRACT The use of plant extracts can be an alternative to reduce the use of pesticides, to control diseases and pests that affect agricultural production. The aim of this study was the chemical characterization of the extract and fractions of Pouteria ramiflora leaves and to determine its fungistatic potential on Lasiodiplodia theobromae. The ethanolic extract of dried and crushed leaves was obtained by maceration. Part of this extract was sequentially partitioned and the following fractions were obtained: hexane, dichloromethane, chloroform, ethyl acetate, n-butyl, and hydromethanol for subsequent bioassay, and qualitative and quantitative phytochemical analysis. Experimental development comprises of adding a L. theobromae mycelial disk (5 mm), obtained... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pathogen; Natural products; Organic farming; Flavonoids. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-05362017000400564 |
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| Arrieta, Jesus M.; Arnaud-haond, Sophie; Duarte, Carlos M.. |
| The marine realm represents 70% of the surface of the biosphere and contains a rich variety of organisms, including more than 34 of the 36 living phyla, some of which are only found in the oceans. The number of marine species used by humans is growing at unprecedented rates, including the rapid domestication of marine species for aquaculture and the discovery of natural products and genes of medical and biotechnological interest in marine biota. The rapid growth in the human appropriation of marine genetic resources (MGRs), with over 18,000 natural products and 4,900 patents associated with genes of marine organisms, with the latter growing at 12% per year, demonstrates that the use of MGRs is no longer a vision but a growing source of biotechnological and... |
| Tipo: Text |
Palavras-chave: Marine protected areas; Marine reserves; Natural products; Gene patents; Law of the sea. |
| Ano: 2010 |
URL: https://archimer.ifremer.fr/doc/00018/12897/9935.pdf |
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| Tahtinen, Petri; Guella, Graziano; Saielli, Giacomo; Debitus, Cecile; Hnawia, Edouard; Mancini, Ines. |
| Arsenicin A (C3H6As4O3) was isolated from the New Caledonian poecilosclerid sponge Echinochalina bargibanti, and described as the first natural organic polyarsenic compound. Further bioguided fractionation of the extracts of this sponge led us to isolate the first sulfur-containing organic polyarsenicals ever found in Nature. These metabolites, called arsenicin B and arsenicin C, are built on a noradamantane-type framework that is characterized by an unusual As-As bonding. Extensive NMR measurements, in combination with mass spectra, enabled the assignment of the structure for arsenicin B (C3H6As4S2) as 2. The scarcity of arsenicin C and its intrinsic chemical instability only allowed the collection of partial spectral data, which prevented the full... |
| Tipo: Text |
Palavras-chave: Antibacterial; Arsenical; Calculated NMR spectrum; Density functional theory; Natural products; NMR spectroscopy; Structure elucidation; Sulfur metabolite. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00469/58051/72242.pdf |
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| Coulombier, Noémie; Nicolau, Elodie; Le Déan, Loic; Barthelemy, Vanille; Schreiber, Nathalie; Brun, Pierre; Lebouvier, Nicolas; Jauffrais, Thierry. |
| Nephroselmis sp. was previously identified as a species of interest for its antioxidant properties owing to its high carotenoid content. In addition, nitrogen availability can impact biomass and specific metabolites’ production of microalgae. To optimize parameters of antioxidant production, Nephroselmis sp. was cultivated in batch and continuous culture conditions in stirred closed photobioreactors under different nitrogen conditions (N-repletion, N-limitation, and N-starvation). The aim was to determine the influence of nitrogen availability on the peroxyl radical scavenging activity (oxygen radical absorbance capacity (ORAC) assay) and carotenoid content of Nephroselmis sp. Pigment analysis revealed a specific and unusual photosynthetic system with... |
| Tipo: Text |
Palavras-chave: Lutein; Natural products; Nutrients; Peroxyl radical; Siphonaxanthin. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00645/75699/76604.pdf |
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| Silva,Ara; Morais,SM; Marques,MMM; Lima,DM; Santos,SCC; Almeida,RR; Vieira,IGP; Guedes,MIF. |
| In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Natural products; Phenols; Dengue; Antiviral agents. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007 |
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| Oliveira,Cláudia S.; Caldeira,Cleópatra A. S.; Diniz-Sousa,Rafaela; Romero,Dolores L.; Marcussi,Silvana; Moura,Laura A.; Fuly,André L.; Carvalho,Cicília de; Cavalcante,Walter L. G.; Gallacci,Márcia; Pai,Maeli Dal; Zuliani,Juliana P.; Calderon,Leonardo A.; Soares,Andreimar M.. |
| Abstract Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from five cnidarians: Millepora alcicornis, Stichodactyla helianthus, Plexaura homomalla, Bartholomea annulata and Condylactis gigantea (total and body wall). Methods: The cnidarian extracts were evaluated by electrophoresis and for their phospholipase, proteolytic, hemorrhagic, coagulant, fibrinogenolytic, neuromuscular blocking, muscle-damaging, edema-inducing and cytotoxic activities. Results: All... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caribbean sea cnidarians; Bioprospection; Antiophidic; Antitumor; Natural products. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100313 |
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| Türkoğlu,E.A; Kuzu,M; Ayasan,T; Inci,H; Eratak,SV. |
| ABSTRACT Thioredoxin reductases (TrxRs) are selenocysteine-containing flavoenzymes that reduce Trxin NADPH-dependent manner. In the view of the direct vital role of TrxR in a wide range of biochemical and physiological processes, methods to inhibit this enzyme are clinically important. TrxR has recently emerged as a new candidate in anticancer drug investigations because of overexpression in tumorous cells. In this study, TrxR from chick liver was purified 94.6-fold with a yield of 4.86% and a specific activity of 0.19 EU/mg. KM and Vmax values of TrxR for DTNB were calculated as 0.9 mM and 0,03 EU/mL, respectively. Then, the effects of the flavonoids hesperidin, naringenin, chlorogenic acid, ferulic acid, naringin, 3,4-dihydoxybenzoic acid, and ellagic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flavonoids; Inhibitors; Natural products; Thioredoxin reductase. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000200345 |
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| Volpato,A; Lorenzetti,WR; Zortea,T; Giombelli,LCDD; Baretta,D; Santos,RCV; Vaucher,RA; Raffin,RP; Souza,ME; Stefani,LM; Boligon,AA; Athayde,ML; Silva,AS da. |
| ABSTRACT The aim of this study was to evaluate the in vitro bioactivity of tea tree (Melaleuca alternifolia) essential oil against larvae and adult forms of lesser mealworms (Alphitobius diaperinus) and its influence on the soil fauna. Tests were performed in triplicate using pure tea tree oil (TTO; 1, 5, 10, 25, 50, and 100%), TTO nanoparticles (1, 3, and 7.5%), or terpinen-4-ol, the main compound of the tea tree oil, at the same concentrations of TTO. Larvae and adult mortality occurred at concentrations up to 10 and 50% of TTO, respectively. No larvicidal or insecticidal effect of TTO nanoparticles was observed. Terpinen-4-ol showed insecticidal and larvicidal effect at concentrations higher than 25%. The evaluation of TTO effect on soil organisms was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alphitobius diaperinus; Essential oil; Natural products; Nanotechnology; Pest management. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2016000100041 |
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| Zulfiqar,Sumer; Ahmed,Sohail; Sufyan,Muhammad; Arshad,Muhammad; Nawaz,Ahmad; Hassan,Babar. |
| Abstract Synthetic wood preservatives are the causes of large-scale environmental pollution and few have been withdrawn from the commercial markets in the past years. The present studies focused on determination of naturally present extractives of Ziziphus mauritiana as less toxic wood protectant against subterranean termites. Firstly, natural resistance of Z. mauritiana heartwood against termite was determined by exposing stakes in the field. For the preparation of extractives, air-dried Z. mauritiana heartwood and bark shavings were soaked in 1 liter each of ethyl acetate, hexane, petroleum ether and water in a bottle separately. Different dipping treatment times (36 and 72 hours) at 10, 20 and 30% concentrations of extractives on Populus deltoides... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Natural products; Wood preservation; Environment friendly; Termite; Wood extracts. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262020000100206 |
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| García Milián,Ana Julia; Avila Pérez,Yeny; Alonso Carbonell,Liuba; López Puig,Pedro; Karelia Ruiz Salvador,Ana; Morón Rodríguez,Francisco. |
| INTRODUCCIÓN: los productos medicinales naturales se pueden utilizar para numerosos problemas de salud. OBJETIVOS: detectar las reacciones adversas asociadas al uso de la medicina natural y clasificar estas reacciones aplicando relación de causalidad y gravedad. MÉTODOS: se realizó un estudio descriptivo, retrospectivo, observacional, longitudinal. Se consideró como elegible para el estudio, el universo conformado por el conjunto de los reportes de posibles reacciones adversas por productos naturales que se utilizaron durante 2003 y 2007. RESULTADOS: se observó un predominio en la frecuencia de aparición de las reacciones adversas a medicamentos en el sexo femenino, los productos más frecuentes fueron ajo (Allium sativum L.), orégano (Plectranthus... |
| Tipo: Journal article |
Palavras-chave: Productos naturales; Medicamentos herbarios; Plantas medicinales; Reacciones adversas; Farmacovigilancia; Natural products; Herbal drugs; Medicinal plants; Adverse reactions; Pharmacosurveillance. |
| Ano: 2009 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962009000100002 |
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| Harvey,Alan L. |
| Natural products are the most consistently successful source of drug leads, both historically and currently. Despite this, the use of natural products in industrial drug discovery has fallen out of favour. Natural products are likely to continue to be sources of new commercially viable drug leads because the chemical novelty associated with natural products is higher than that of any other source: this is particularly important when searching for lead molecules against newly discovered targets for which there are no known small molecule leads. Despite the commonly held assumptions, natural products can be a more economical source of chemical diversity compared with synthesis of equivalent numbers of diverse chemicals. Additionally, natural products that... |
| Tipo: Journal article |
Palavras-chave: Drug discovery; Natural products; High throughput screening; Convention on biological diversity. |
| Ano: 2009 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0253-570X2009000100002 |
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| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; JENSEN,Bruno Bezerra; GRAFOVA,Iryna; SANTOS,Pierre Alexandre dos; BARROS,Angela Maria Comapa; SOARES,Fabiane Veloso; BARCELLOS,José Fernando Marques; SILVA,Aline Fagundes da; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extract of L. ferrea on golden hamsters infected with L. (L.) amazonensis. Extracts from leaves, branches and fruits of L. ferrea were obtained with hexane and methanol and were tested by in vitro assays in promastigotes and murine macrophages J774... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cutaneous leishmaniasis; Natural products; Topical formulations; Experimental treatment. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000400331 |
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| Cruz,Carolinie Batista Nobre da; Pieri,Fabio Alessandro; Carvalho-Zilse,Gislene Almeida; Orlandi,Patrícia Puccinelli; Nunes-Silva,Carlos Gustavo; Leomil,Luciana. |
| Honeys are described possessing different properties including antimicrobial. Many studies have presented this activity of honeys produced by Apis mellifera bees, however studies including activities of stingless bees honeys are scarce. The aim of this study was to compare the antimicrobial activity of honeys collected in the Amazonas State from Melipona compressipes, Melipona seminigra and Apis mellifera against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Chromobacterium violaceum, and Candida albicans. Minimum inhibitory concentrations were determined using the agar dilution method with Müller-Hinton agar (for bacteria) or Saboraud agar (for yeast). Staphylococcus aureus and E. faecalis were inhibited by all honeys at concentrations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Melipona; Antibacterial; Antifungal; Natural products; Functional food. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200015 |
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| Registros recuperados: 48 | |
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