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	Provedor de dados Anais da ABC (AABC) (2) BJMBR (2) Autor De-Miguel,F.F. (1) MENDEZ-OTERO,ROSALIA (1) Mendez-Otero,R. (1) SANTIAGO,MARCELO F. (1) Santiago,M.F. (1) TARDY,MARCIENNE (1) Mais... Palavra-chave Neurite outgrowth (4) 9-O-acetyl GD3 (2) Development (2) Neuronal migration (2) Astrogliosis (1) Cultured neurons (1) Ganglioside (1) Gangliosides (1) Glycolipid (1) Laminin (1) Leech (1) Metalloproteinases (1) Neuro-glia interactions (1) Neuronal Migration (1) Regeneration (1) Synapse formation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2003 (1) 2002 (1) 2001 (1) 2000 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth Anais da ABC (AABC) TARDY,MARCIENNE. The mechanisms involved in the failure of an adult brain to regenerate post-lesion remain poorly understood. The reactive gliosis which occurs after an injury to the CNS and leads to the glial scar has been considered as one of the major impediments to neurite outgrowth and axonal regeneration. A glial scar consists mainly of reactive, hypertrophic astrocytes. These reactive cells acquire new properties, leading to A non-permissive support for neurons. Astrogial reactivity is mainly characteriized by a high overexpression of the major component of the gliofilaments, the glial fibrillary acidic protein (GFAP). This GFAP overexpression is related to the astroglial morphological response to injury. We hypothesized that modulation of GFAP synthesis, reversing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Astrogliosis; Neuro-glia interactions; Neurite outgrowth; Neuronal migration; Laminin; Metalloproteinases. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000400009 Functional role of a glycolipid in directional movements of neurons Anais da ABC (AABC) MENDEZ-OTERO,ROSALIA; SANTIAGO,MARCELO F.. Migration of neurons from their site of origin to their final destination is a critical and universal step in the formation of the complex structure of the nervous system. The migratory process is thought to be governed in part by genetically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neuronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migration. Some molecules, such as cell adhesion molecules and motor proteins, may contribute to discrete steps in the migration act; others, like extracellular signaling molecules, may regulate the activation and/or termination of the migration... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycolipid; Ganglioside; 9-O-acetyl GD3; Neuronal Migration; Neurite outgrowth; Development. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000200007 Steps in the formation of neurites and synapses studied in cultured leech neurons BJMBR De-Miguel,F.F.. Leech neurons in culture have provided novel insights into the steps in the formation of neurite outgrowth patterns, target recognition and synapse formation. Identified adult neurons from the central nervous system of the leech can be removed individually and plated in culture under well-controlled conditions, where they retain their characteristic physiological properties, grow neurites and form specific chemical or electrical synapses. Different identified neurons develop distinctive outgrowth patterns that depend on their identities and on the molecular composition of the substrate. On native substrates, the patterns displayed by these neurons reproduce characteristics from the adult or the developing neurons. In addition, the substrate may induce... Tipo: Info:eu-repo/semantics/article Palavras-chave: Regeneration; Neurite outgrowth; Synapse formation; Cultured neurons; Leech. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500002 Functional role of a specific ganglioside in neuronal migration and neurite outgrowth BJMBR Mendez-Otero,R.; Santiago,M.F.. Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuronal migration; Gangliosides; Development; 9-O-acetyl GD3; Neurite outgrowth. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006 Registros recuperados: 4 Primeira ... 1 ... Última

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