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Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas Anais da ABC (AABC)
CUNHA,KARIN S.; CARUSO,ANABELA C.; FARIA,PAULO A.; SILVA,LICíNIO E. DA; FONSECA,ELIENE C. DA; GELLER,MAURO; MOURA-NETO,RODRIGO S. DE; LOPES,VÂNIA S..
ABSTRACTAIMSTo study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated.MATERIALS AND METHODSThe evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis.CONCLUSIONSApoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis regulatory proteins; Malignant peripheral nervous sheath tumors; Neurofibroma; Neurofibromatosis 1.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497
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Intraparotid Facial Nerve Neurofibroma: an Uncommon Neoplasm International Journal of Morphology
Sethi,Ashwani; Chopra,Shamit; Passey,J. C; Agarwal,A. K.
Intraparotid facial nerve neurofibromas are a rare entity, and are grossly and histopathologically distinct from the comparatively more prevalent schwannomas. We report a rare case of an intraparotid facial nerve neurofibroma with intratemporal extension in a 48-year-old female. The tumor was surgically excised with cable grafting of the facial nerve. Electroneurography may eventually assist in the preoperative diagnosis. Facial nerve resection should be more readily contemplated in a patient with neurofibroma than in a patient with schwannoma; however, facial nerve preservation with serial follow-up electroneurography and computerized tomography remains a viable option in patients with small facial nerve neurofibromas when electrical testing reveals...
Tipo: Journal article Palavras-chave: Facial nerve; Neurofibroma; Parotid gland; Temporal bone; Nerve grafting.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300066
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