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| Rufino,Marcos Natal; Cereda,Marney Pascoli; Barreto,Wanessa Teixeira Gomes; Silva,Alanderson Rodrigues da; Andrade,Gisele Braziliano de; Herrera,Heitor Miraglia. |
| ABSTRACT Cassava has been widely used for animal and human nutrition. It has also been demonstrated to have antineoplastic and anthelmintic properties. Toxicity due to cassava consumption has been reported in ruminants and laboratory animals; therefore, this study aimed to investigate the toxic effects of acetone cyanohydrin, a metabolite of linamarin that is present in cassava, in Wistar rats. Six groups of five animals each were used to evaluate the toxic effects of acetone cyanohydrin administered at 25 (G1), 50 (G2), 75 (G3), 100 (G4) and 125 (G5) µmol/kg as a single oral dose. The control group received acidified water (pH 3.5). The animals were monitored after administration of acetone cyanohydrin, and clinical symptoms were recorded. Serum enzyme... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurotoxic; Hepatotoxic; Cyanide; Acute intoxication. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542016000500577 |
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| Blanc, Mélanie; Cormier, Bettie; Hyötyläinen, Tuulia; Krauss, Martin; Scherbak, Nikolai; Cousin, Xavier; Keiter, Steffen H.. |
| Transgenerational effects induced by environmental stressors are a threat to ecosystems and human health. However, there is still limited observation and understanding of the potential of chemicals to influence life outcomes over several generations. In the present study, we investigated the effects of two environmental contaminants, coumarin 47 and permethrin, on exposed zebrafish (F0) and their progeny (F1–F3). Coumarin 47 is commonly found in personal care products and dyes, whereas permethrin is used as a domestic and agricultural pyrethroid insecticide/insect repellent. Zebrafish (F0) were exposed during early development until 28 days post-fertilization and their progeny (F1–F3) were bred unexposed. On one hand, the effects induced by coumarin 47... |
| Tipo: Text |
Palavras-chave: Pyrethroid; Endocrine disrupter; Epigenetic; Transgenerational; Neurotoxic. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00652/76393/77411.pdf |
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