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	Provedor de dados BJMBR (2) Autor Araujo,E.G. (1) Guilarducci,C.V.V. (1) Moon,L.D.F. (1) Oudega,M. (1) Torres,P.M.M. (1) de Almeida Leme,R.J. (1) Mais... Palavra-chave Neurotrophic factors (2) Clinical trial (1) Cytokines (1) Gene profiling (1) Implantation (1) Regeneration (1) Rehabilitation (1) Retina (1) Schwann cells (1) Sciatic nerve (1) Spinal cord injury (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2005 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects of sciatic-conditioned medium on neonatal rat retinal cells in vitro BJMBR Torres,P.M.M.; Guilarducci,C.V.V.; Araujo,E.G.. Schwann cells produce and release trophic factors that induce the regeneration and survival of neurons following lesions in the peripheral nerves. In the present study we examined the in vitro ability of developing rat retinal cells to respond to factors released from fragments of sciatic nerve. Treatment of neonatal rat retinal cells with sciatic-conditioned medium (SCM) for 48 h induced an increase of 92.5 ± 8.8% (N = 7 for each group) in the amount of total protein. SCM increased cell adhesion, neuronal survival and glial cell proliferation as evaluated by morphological criteria. This effect was completely blocked by 2.5 µM chelerythrine chloride, an inhibitor of protein kinase C (PKC). These data indicate that PKC activation is involved in the effect... Tipo: Info:eu-repo/semantics/other Palavras-chave: Cytokines; Neurotrophic factors; Retina; Schwann cells; Sciatic nerve. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100012 Schwann cells for spinal cord repair BJMBR Oudega,M.; Moon,L.D.F.; de Almeida Leme,R.J.. The complex nature of spinal cord injury appears to demand a multifactorial repair strategy. One of the components that will likely be included is an implant that will fill the area of lost nervous tissue and provide a growth substrate for injured axons. Here we will discuss the role of Schwann cells (SCs) in cell-based, surgical repair strategies of the injured adult spinal cord. We will review key studies that showed that intraspinal SC grafts limit injury-induced tissue loss and promote axonal regeneration and myelination, and that this response can be improved by adding neurotrophic factors or anti-inflammatory agents. These results will be compared with several other approaches to the repair of the spinal cord. A general concern with repair strategies... Tipo: Info:eu-repo/semantics/article Palavras-chave: Spinal cord injury; Implantation; Regeneration; Neurotrophic factors; Clinical trial; Rehabilitation; Gene profiling. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600003 Registros recuperados: 2 Primeira ... 1 ... Última

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