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Divergent effects of Nitric oxide on airway epithelial cell activation Biol. Res.
Neri,Tommaso; Conti,Ilaria; Cerri,Chiara; Tavanti,Laura; Paggiaro,Pierluigi; Celi,Alessandro.
Nitric oxide (NO*) is a gaseous mediator synthesized by Nitric oxide sinthases. NO* is involved in the modulation of inflammation, but its role in airway inflammation remains controversial. We investigated the role of NO* in the synthesis of the chemok Nes Interleukin-8 and Monocyte Chemotactic Protein-1, and of Intercellular Adhesion Molecule-1 by human airway epithelial cells. normal human bronchial epithelial cells and the bronchial epithelial cell line BEAS-2B were used. Neterleukin-8 (IL-8) and Monocyte Chemotactic Protein-1 (MCP-1) secretion and Intercellular Adhesion Molecule-1 (ICAM-1) expression were measured by ELISA. mRNA was assessed by semiquantitative RTI-PCR. Neterleukin-8 secretion was significantly reduced after 24h incubation with the NO*...
Tipo: Journal article Palavras-chave: Adhesion molecules; Airway inflammation; Alveolar Epithelium; Chemok Nes; Nitric Oxide.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400012
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