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| Sbragia,L.; Nassr,A.C.C.; Gonçalves,F.L.L.; Schmidt,A.F.; Zuliani,C.C.; Garcia,P.V.; Gallindo,R.M.; Pereira,L.A.V.. |
| Changes in vascular endothelial growth factor (VEGF) in pulmonary vessels have been described in congenital diaphragmatic hernia (CDH) and may contribute to the development of pulmonary hypoplasia and hypertension; however, how the expression of VEGF receptors changes during fetal lung development in CDH is not understood. The aim of this study was to compare morphological evolution with expression of VEGF receptors, VEGFR1 (Flt-1) and VEGFR2 (Flk-1), in pseudoglandular, canalicular, and saccular stages of lung development in normal rat fetuses and in fetuses with CDH. Pregnant rats were divided into four groups (n=20 fetuses each) of four different gestational days (GD) 18.5, 19.5, 20.5, 21.5: external control (EC), exposed to olive oil (OO), exposed to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Congenital diaphragmatic hernia; VEGFR; Rat model; Nitrofen; Lung development. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200171 |
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