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Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease BJMBR
Santos,V.N. dos; Leite-Mór,M.M.B.; Kondo,M.; Martins,J.R.; Nader,H.; Lanzoni,V.P.; Parise,E.R..
Hepatic fibrosis in patients with non-alcoholic fatty liver disease is associated with progression of the disease. In the present study, we analyzed the discriminative ability of serum laminin, type IV collagen and hyaluronan levels to predict the presence of fibrosis in these patients. In this preliminary report, we studied 30 overweight patients divided into two groups according to the absence (group I, N = 19) or presence (group II, N = 11) of fibrosis in a liver biopsy. Triglycerides, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidade, hyaluronan (noncompetitive fluoroassay), type IV collagen, and laminin (ELISA) were determined. Group II presented significantly higher mean laminin, hyaluronan, type IV collagen, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic fibrosis; Hyaluronan; Laminin; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Type IV collagen.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500012
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Conjugated linoleic acid supplementation: lipid content and hepatic histology in healthy Wistar rats Ciênc. Tecnol. Aliment.
Santos-Zago,Lilia Ferreira; Botelho,Adriana Prais; Oliveira,Admar Costa de; Maróstica Junior,Mário Roberto.
This work aimed to evaluate the effects of the consumption of two commercial conjugated linoleic acid (CLA) mixtures on lipid content and liver histology of healthy rats. The investigation was carried out using thirty rats divided into three groups: C (control), AE (AdvantEdge®CLA), and CO (CLA One®). The concentration of CLA was 2% of feed consumption, and the animals were supplemented daily for 42 days. The total lipid content of the liver was determined, and the histology of the organ was examined by Transmission Electronic Microscopy. The results of total liver lipid contents did not exhibit significant differences between the groups. With regard to hepatic histology, it was observed that although fat globules were visibly present in higher numbers and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trans fatty acid; Liver integrity; Oxidative stress; Non-alcoholic steatohepatitis.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612011000100020
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