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	Provedor de dados BJPS (1) Autor Silva,Taízia Dutra (1) Toledo,Cibele Rodrigues (1) Vianna-Soares,Cristina Duarte (1) Palavra-chave Derivative ultraviolet spectrophotometry (1) Non-aqueous acid-base titrimetry (1) Sildenafil citrate (1) Sildenafil citrate/quality control. (1) Vasodilator (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets BJPS Silva,Taízia Dutra; Toledo,Cibele Rodrigues; Vianna-Soares,Cristina Duarte. Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by derivative ultraviolet spectrophotometry (DUS) in active pharmaceutical ingredient and/or dosage forms. The quantitation method of SILC active pharmaceutical ingredient by non-aqueous acid-base titration was developed using methanol as solvent and 0.1 mol/L of perchloric acid in acetic acid as titrant. The endpoint was potentiometrically detected. The non-aqueous titration method shows satisfactory repeatability and intermediate precision (RSD 0.70-1.09%). The neutralization reaction occurred in the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sildenafil citrate; Vasodilator; Derivative ultraviolet spectrophotometry; Non-aqueous acid-base titrimetry; Sildenafil citrate/quality control.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100608 Registros recuperados: 1 Primeira ... 1 ... Última

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