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	Provedor de dados Anais da ABC (AABC) (1) Genet. Mol. Biol. (1) Autor Ding,Jiayi (1) Liang,Qiaoyi (1) Mattick,John S. (1) Zheng,Shu (1) Palavra-chave Noncoding RNA (2) Brain (1) Development (1) Endogenous retrovirus (1) Epigenome (1) Gene regulation (1) Quantitative real-time PCR (1) RNA editing (1) RT-PCR (1) Transcription (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The central role of RNA in the genetic programming of complex organisms Anais da ABC (AABC) Mattick,John S.. Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain. Tipo: Info:eu-repo/semantics/article Palavras-chave: Development; Noncoding RNA; Epigenome; Gene regulation; RNA editing; Brain. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000400016 Identification and detection of a novel human endogenous retrovirus-related gene, and structural characterization of its related elements Genet. Mol. Biol. Liang,Qiaoyi; Ding,Jiayi; Zheng,Shu. Up-regulation of human endogenous retroviruses (HERVs) is associated with many diseases, including cancer. In this study, an H family HERV (HERV-H)-related gene was identified and characterized. Its spliced transcript lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs). The 1.3-kb RNA consisting of four exons is transcribed from an Alu element upstream of a 5.0-kb structurally incomplete HERV-H element. RT-PCR and quantitative RT-PCR results indicated that expression of this HERV-related transcript was negatively associated with colon, stomach, and kidney cancers. Its expression was induced upon treatment with DNA methylation and histone deacetylation inhibitors. A BLAT search using long terminal repeats (LTRs)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endogenous retrovirus; Noncoding RNA; RT-PCR; Quantitative real-time PCR; Transcription. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400005 Registros recuperados: 2 Primeira ... 1 ... Última

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