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| HERRERA-RIVERO,MARISOL; SOTO-CID,ABRAHAM; HERNáNDEZ,MARíA E.; ARANDA-ABREU,GONZALO E.. |
| Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes during normal compared to neuropathological ageing. We analysed the expression of tau, of the amyloid precursor protein, of nicastrin and of the β-site APP cleaving enzyme genes by RT-PCR in lymphocytes from a small group of late-onset Alzheimer's disease patients, from aged patients suffering from neuropsychological conditions different from Alzheimer's and from cognitively healthy subjects divided in four groups by age. We also investigated correlations between gene expression and levels of blood pressure,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alzheimer's disease; APP; BACE1; Nicastrin; Normal ageing; Risk factors. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401489 |
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