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	Provedor de dados BJMBR (1) Autor Han,S.W. (1) Kanashiro,C.A. (1) Krieger,J.E. (1) Merjan,A.J. (1) Paiva,A.C.M. (1) Palavra-chave Agonist-induced receptor internalization (1) Angiotensin II (1) Endocytosis (1) Fluorescence-tagged receptor (1) Nuclear angiotensin receptors (1) Renin-angiotensin system (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Ligand-induced endocytosis and nuclear localization of angiotensin II receptors expressed in CHO cells BJMBR Merjan,A.J.; Kanashiro,C.A.; Krieger,J.E.; Han,S.W.; Paiva,A.C.M.. A construct (AT1R-NF) containing a "Flag" sequence added to the N-terminus of the rat AT1 receptor was stably expressed in Chinese hamster ovary cells and quantified in the cell membrane by confocal microscopy after reaction with a fluorescein-labeled anti-Flag monoclonal antibody. Angiotensin II bound to AT1R-NF and induced endocytosis with a half-time of 2 min. After 60-90 min, fluorescence accumulated around the cell nucleus, suggesting migration of the ligand-receptor complex to the nuclear membrane. Angiotensin antagonists also induced endocytosis, suggesting that a common step in the transduction signal mechanism occurring after ligand binding may be responsible for the ligand-receptor complex internalization. Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Agonist-induced receptor internalization; Endocytosis; Fluorescence-tagged receptor; Nuclear angiotensin receptors; Renin-angiotensin system. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900011 Registros recuperados: 1 Primeira ... 1 ... Última

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