|
|
|
|
|
| Zambonino, Jose-luis; Cahu, Chantal. |
| During these last 20 years, many studies have focussed on the development of the digestive tract in marine fish larvae. Most of the studies aimed at acquiring knowledge on the optimal form of dietary supply for different nutrients, in order to formulate a compound diet able to totally replace live preys in the fish larvae feeding sequence. Consequently, most of the studies aimed at describing the effect of dietary adaptation on digestive enzymes profile, the morphology of the main organs, while others aspects of the physiology of the larvae digestive tract (gut hormones, intestinal transport...) were poorly investigated. This review reports the more recent data on dietary modulation of digestive enzymes with a particular emphasis, when possible, on the... |
| Tipo: Text |
Palavras-chave: Nuclear receptors; Digestive enzymes; Fatty acids; Vitamins; Dietary proteins and lipids; Fish larvae. |
| Ano: 2007 |
URL: http://archimer.ifremer.fr/doc/2007/publication-3045.pdf |
| |
|
|
| Yang, Chunyan; Li, Qianrong; Li, Yong. |
| Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, the discovery of novel ligands for nuclear receptors represents an interesting and promising therapeutic approach. The search for novel NR agonists and antagonists with enhanced selectivities prompted the exploration of the extraordinary chemical diversity associated with natural products. Recent studies involving nuclear receptors have disclosed a number of natural products as nuclear receptor ligands, serving to re-emphasize the translational possibilities of natural products in drug... |
| Tipo: Text |
Palavras-chave: Nuclear receptors; Marine natural products; Ligands; Screen; Drug targets. |
| Ano: 2014 |
URL: https://archimer.ifremer.fr/doc/00468/57924/60259.pdf |
| |
|
|
| Festa, Carmen; D'Amore, Claudio; Renga, Barbara; Lauro, Gianluigi; De Marino, Simona; D'Auria, Maria Valeria; Bifulco, Giuseppe; Zampella, Angela; Fiorucci, Stefano. |
| Further purification of the apolar extracts of the sponge Plakinastrella mamillaris, afforded a new oxygenated polyketide named gracilioether K, together with the previously isolated gracilioethers E-G and gracilioethers I and J. The structure of the new compound has been elucidated by extensive NMR (H-1 and C-13, COSY, HSQC, HMBC, and ROESY) and ESI-MS analysis. With the exception of gracilioether F, all compounds are endowed with potent pregnane-X-receptor (PXR) agonistic activity and therefore represent a new chemotype of potential anti-inflammatory leads. Docking calculations suggested theoretical binding modes of the identified compounds, compatible with an agonistic activity on hPXR, and clarified the molecular basis of their biological activities. |
| Tipo: Text |
Palavras-chave: Marine sponge; Plakinastrella mamillaris; Oxygenated polyketide; Nuclear receptors; Pregnane-X-receptor; Anti-inflammatory activity. |
| Ano: 2013 |
URL: https://archimer.ifremer.fr/doc/00217/32781/31238.pdf |
| |
|
|
| Carrara,V.S.; Amato,A.A.; Neves,F.A.R.; Bazotte,R.B.; Mandarino,J.M.G.; Nakamura,C.V.; Filho,B.P.D.; Cortez,D.A.G.. |
| Since the anti-inflammatory, antidiabetic and hypolipidemic effects of soy isoflavones may be mediated by activation of peroxisome proliferator-activated receptors (PPAR), the present study investigated whether the methanolic fractions obtained from soybean seeds (E1) and soybean seed coats with hypocotyls (E2) could influence PPARα, PPARγ and PPARβ/δ transcriptional activity. The isoflavones from E1 and E2 were quantified by HPLC analysis. E1 and E2 were rich in isoflavones (daidzin, glycitin, genistin, malonyldaidzin, malonylglycitin, malonylgenistin, daidzein, glycitein, and genistein). Moreover, E1 and E2 showed no evidence of genetically modified material containing the gene CP4 EPSPS. To investigate PPAR transcriptional activity, human promonocytic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Isoflavones; Nuclear receptors; Soybean; PPARα; PPARγ; PPARβ/δ. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600011 |
| |
|
|
|
