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| Registros recuperados: 197 | |
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| Errera,Flavia I.V.; Canani,Luís H.; Yeh,Erika; Kague,Érika; Armelin-Corrêa,Lucia M.; Suzuki,Oscar T.; Tschiedel,Balduíno; Silva,Maria Elizabeth R.; Sertié,Andréa L.; Passos-Bueno,Maria Rita. |
| Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII and Wnt signaling have recently been associated with adipogenic differentiation and obesity in some animal models, but not in humans. In the present report, we have shown that COL18A1 expression increases during human adipogenic differentiation. We also tested if polymorphisms in the Frizzled (c.1136C>T; Thr379Met) and Endostatin (c.4349G>A; Asp1437Asn) regions contribute towards susceptibility to obesity in patients with type 2 diabetes (113 obese, BMI =30; 232 non-obese, BMI < 30) of European ancestry. No evidence of association... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: COL18A1; Obesity; Adipogenesis; Endostatin; Frizzled. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100012 |
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| MORAES,GREICE G.; REUTER,CÉZANE P.; RENNER,JANE D.P.; KLINGER,ELISA I.; FERREIRA,MICHELE B.; MELLO,ELZA D. DE; VALIM,ANDRÉIA DE M.; BURGOS,MIRIA S.. |
| ABSTRACT Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotype; Intervention; Obesity; Children; Physical activity. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331 |
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| CARVALHO,ANGELA A. M.; MOURA,FRANCYELLE B. R. DE; NOGUEIRA,PEDRO AUGUSTO S.; GONÇALVES,ALINE MARIA N.; ARAÚJO,FERNANDA A.; ZANON,RENATA G.; TOMIOSSO,TATIANA CARLA. |
| Abstract Obesity is characterized by the excess of body fat and, therefore, may cause musculoskeletal alterations that can negatively influence the tendons. Such overweight-influenced alterations are exercise sensitive though. Morphological and biochemical alterations were reported in the calcaneal tendon of mice submitted to a lipid-rich diets along with practicing exercises, with the following groups: normal diet without exercise (ND), normal diet with exercise (NDex), lipid-rich diet without exercise (LD), lipid-rich diet without exercise (LDex). The calcaneal tendons were removed and subjected to histological and biochemical analysis. Layers of the tissue were stained with Hematoxylin and Eosin, Picrosirius Red and Von Kossa while a protein dosage was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diet; Hematoxylin-eosin; Obesity; Tendon; Von Kossa. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100909 |
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| LIPINSKI,LEANDRO C.; KMETIUK,LOUISE B.; MATHIAS,PAULO C.F.; MALTA,ANANDA; FAVERO,GIOVANI M.; RIBEIRO,TATIANE A.; TOLEDO,ALCEU; NETTO,MARIO R. MONTEMOR; RODRIGUES,MARCOS R.S.. |
| ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oral insulin; Intestine; Diabetes; Obesity; Metabolism; Pancreatic beta-cell. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401699 |
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| SANTOS,CAROLYNE D.S.; BALBO,SANDRA L.; GUIMARÃES,ANA T.B.; SAGAE,SARA C.; NEGRETTI,FÁBIO; GRASSIOLLI,SABRINA. |
| ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria diet throughout life, including pregnancy and lactation). After birth, only male offspring (F1) were maintained and received the CTL or CAF diets; originating four experimental groups: CTL-CTLF1; CTL-CAFF1; CAF-CTLF1; CAF-CAFF1. Data of biometrics, metabolic parameters, liver, BAT and WAT histology were assessed and integrated using the Principal Component Analysis (PCA). According to PCA analysis worse... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Dams; Offspring; Histology. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602887 |
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| Medeiros,Magda A.; Costa-e-Sousa,Ricardo H.; Olivares,Emerson L.; Côrtes,Wellington S.; Reis,Luís C.. |
| The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food ingestion; Serotonergic system; Dorsal raphe nucleus; Electrolytic lesion; Para-chlorophenylalanine; Obesity. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008 |
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| SIMÃO,ANDERSON A.; MARQUES,TAMARA R.; MARCUSSI,SILVANA; CORRÊA,ANGELITA D.. |
| ABSTRACT Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions. The compounds identified are gallic acid, epigallocatechin gallate, syringic acid, o-coumaric acid, resveratrol, quercetin, and catechin (which was the major... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medicinal plants; Obesity; Α-amylase; Α-glycosidase; Lipase; Trypsin. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502155 |
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| CELIK,HAKIM; KILIC,TUGBA; KAPLAN,DAVUT S.; EREN,MEHMET A.; EREL,OZCAN; KARAKILCIK,ALI Z.; BAGCI,CAHIT. |
| Abstract: We studied dynamic thiol/disulphide homeostasis, an indicator of oxidative stress, to investigate the effects of newly initiated exercise training on sedentary obese adults. Seventeen sedentary obese adults and 15 normal-weight controls were included in the sample for this study. The obese adults were given a physical exercise training program that lasted twelve weeks. Before and after the exercise training program, blood samples were collected, and serum thiol/disulphide parameters were measured by using a novel technique. Before the start of the exercise training, it was observed that thiol/disulphide homeostasis was impaired, and this impairment was positively correlated with body mass index in sedentary obese adults because of the higher... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise; Obesity; Oxidative stress; Thiol / disulphide homeostasis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700805 |
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| Todendi,Pâmela F.; Klinger,Elisa I.; Ferreira,Michele B.; Reuter,Cézane P.; Burgos,Miria S.; Possuelo,Lia G.; Valim,Andréia R.M.. |
| Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction(PCR). Anthropometric... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Inflammation; Obesity; Polymorphisms; Risk; Schoolchildren. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200915 |
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| Nascimento,Ozanildo V; Boleti,Ana P.A; Yuyama,Lucia K.O; Lima,Emerson S. |
| Amazonian Camu-camu fruit (Myrciaria dubia HBK Mc Vaugh) has attracted interest from food and cosmetics industries because of its rich content of vitamin C, flavonoids and anthocyanins. The goal of this study was investigates the antiobesity action of the ingestion of the Camu-camu pulp in a rat model of diet-induced obesity. Wistar rats with obesity induced by subcutaneous injection of monosodium glutamate receiving diet ad libitum. The rats were divided in two groups: an experimental group that ingested 25 mL/day of Camu-camu pulp (CCG) and a non treated group (CG). After 12 weeks, the animals were sacrificed. Blood, liver, heart, white adipose tissues were collected and weighted, biochemical and inflammatory profiles were determinate as well. Animals... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amazonian fruit; Flavonoids; Lipid profile; Myrciaria dubia; Obesity. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100355 |
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| ALVES,ANA SOFIA R.; VENÂNCIO,TELMA L.; HONÓRIO,SAMUEL ALEXANDRE A.; MARTINS,JÚLIO MANUEL C.. |
| Abstract: Introduction: The aim of the study was to compare the effects of ten-week multicomponent training with different exercise frequencies on body composition (BC) and physical fitness (PF) in overweight and obese young children. Methods: 40 children, aged 12-15 (14.77±1.49), were randomly selected and assigned to experimental groups to train three times/week (EG1) or two times/week (EG2) for 10 weeks and a CG group (no training program). Results: It was shown that experimental groups (EG1 and EG2) improved similarly aerobic capacity (3.8% and 3.5%, respectively), muscular strength (29.7% and 25.2%), flexibility (6.1% and 9.9%), body mass index (5.0% and 4.6%), and body fat (6.4% and 5.6%) from pre- to post-training. CG group showed no significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aerobic; Health; Obesity; Strength; Youth; Program. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700802 |
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| Souza,I.B.R.; Cardoso,C.V.; Pereira,A.A.F.; Poppe,S.C.; Bondan,E.F.. |
| RESUMO Em seres humanos, a adiponectinemia está associada à obesidade e ao risco aumentado a uma ampla variedade de cânceres. Embora o papel dessa adipocina esteja bem documentado na patogênese do câncer em humanos, tal associação permanece a ser determinada em cães. Nesses animais, a relação da adiponectina com a carcinogênese parece ser ainda meramente especulativa. Nesse contexto, buscou-se nesta investigação comparar os níveis séricos de adiponectina em fêmeas hígidas e em portadoras de carcinomas mamários com diagnóstico histopatológico de carcinoma mamário tubular simples estágio 4, com comprometimento de linfonodos, porém sem metástases a distância detectadas. Foi observado que as cadelas diagnosticadas com carcinoma mamário tiveram níveis séricos... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Dogs; Adiponectin; Cancer; Mammary gland; Obesity. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000501741 |
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| Castillo,C.A.; Jaramillo,C.; Loaiza,M.J.; Blanco,R.. |
| ABSTRACT The equine metabolic syndrome is a condition that can be recognized because of obesity, insulin resistance and laminitis. Genetic factors could play a role in the occurrence of this syndrome. Certain breeds such as ponies (including the South American creole horses) have a lower sensibility to insulin and a higher prevalence of hyperinsulinemia. The environment and management conditions, such as overfeeding and lack of exercise are factors that bring a propensity for obesity. The adipose tissue works as an endocrine organ producing hormones (adipokines or adipocytokines) that affect the horse´s metabolism. The objective of this report is to describe the first case report of a Colombian creole mare with a metabolic syndrome, diagnosed by means of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Equine; Insulin resistance; Obesity; Laminitis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000501067 |
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| Teixeira,S.V.; Silva,I.L.D.; Nunes,F.C.; Campos,C.B.; Oliveira,M.R.; Lavalle,G.E.; Cassali,G.D.. |
| ABSTRACT The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bitches; Obesity; Overweight; Mammary carcinomas; Stage. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100143 |
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| Shabana,; Hasnain,Shahida. |
| BACKGROUND: Obesity is a complex disorder and has been increasing globally at alarming rates including Pakistan. However, there is scarce research on understanding obesity genetics in Pakistan. Leptin is a hormone secreted by adipocytes in response to satiety and correlates with body weight. Any mutations in the LEP gene have an adverse effect on energy regulation pathway and lead to severe, early onset obesity. To date, only eight mutations have been described in the LEP gene of which p. N103K is one. METHODS: We aimed to analyze the prevalence of this mutation in Pakistani subjects. A total of 475 subjects were genotyped by PCR-RFLP analysis and their serum profiling was done. RESULTS: Results showed that this mutation was present only in one male child... |
| Tipo: Journal article |
Palavras-chave: Obesity; Leptin; P. N103K; Pakistan. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100023 |
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| VARELA,NELSON M; QUIÑONES,LUIS A; ORELLANA,MYRIAM; PONIACHIK,JAIME; CSENDES,ATTILA; SMOK,GLADYS; RODRIGO,RAMÓN; CÁCERES,DANTE D; VIDELA,LUIS A. |
| CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene. The aim of this study was to investigate hepatic levels, activity, and polymorphisms of the CYP2E1 gene to correlate it with clinical and histological features in 48 female obese NASH patients. Subjects were divided into three groups: (i) normal; (ii) steatosis; and (iii) steatohepatitis. CYP2E1 protein level was assayed in microsomes from liver biopsies, and in vivo chlorzoxazone hydroxylation was determined by HPLC. Genomic DNA was isolated for genotype analysis through PCR. The results showed that liver CYP2E1 content was significantly higher in the steatohepatitis (45%; p=0.024)... |
| Tipo: Journal article |
Palavras-chave: Steatohepatitis; NASH; CYP2E1; Obesity; Genotype; Chlorzoxazone. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100010 |
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| Registros recuperados: 197 | |
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