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Occult hepatitis B virus infection in immunocompromised patients BJID
Jardim,Ruth Nogueira Cordeiro Moraes; Gonçales,Neiva Sellan Lopes; Pereira,Josiane Silveira Felix; Fais,Viviane Cristina; Gonçales Junior,Fernando Lopes.
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Occult HBV infection; HBV-DNA; Anti-HBc alone; Hemodialysis; HIV; Immunosupressed patients.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008
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HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors BJMBR
Pereira,J.S.F.; Gonçales,N.S.L.; Silva,C.; Lazarini,M.S.K.; Pavan,M.H.P.; Fais,V.C.; Gonçales Júnior,F.L..
Anti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV) infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in the sera of patients with chronic hepatitis C virus (HCV) infection, even in the absence of serum HBsAg. Initially we searched for HBV-DNA in serum of 100 blood donors and 50 HCV-infected patients who were HBsAg negative/anti-HBc positive by nested-PCR and by an HBV monitor commercial test for HBV-DNA. Anti-HBs seroconversion rates were measured in 100 blood donors and in 22 patients with chronic HCV infection after HBV vaccination to determine if the HBV vaccination could eliminate an occult HBV infection...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymerase chain reaction; Anti-HBc-positive patients; HCV co-infection; HBV vaccination; Occult HBV infection.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400013
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