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Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease 60
Gaikwad,Swati Sanjay; Chafle,Sandip Annaji; Morris,Princy Sunil; Avari,Jasmine Gev.
ABSTRACT The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The formulations comprise of cefixime trihydrate as immediate release layer formulated using different superdisintegrants and ofloxacin as extended release layer containing HPMC K100M. Evaluation of bilayer tablets were performed for the immediate release cefixime layer and sustain release ofloxacin layer with optimization of excipients. The immediate release layer of cefixime showed complete release within...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sexually transmitted diseases/treatment; Bilayer tablets; Cefixime trihydrate; Ofloxacin..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300555
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