|
|
|
|
|
| OLIVEIRA,JADE DE; STRALIOTTO,MARCOS R.; MANCINI,GIANNI; FIGUEIREDO,CLAUDIA P.; BRAGA,ANTÔNIO L.; TEIXEIRA,JOÃO B.R.; BEM,ANDREZA F.. |
| ABSTRACT Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organoselenium compounds have demonstrated promising atheroprotective properties in experimental models. Herein, we tested the in vitro atheroprotective capability of a modified organoselenium compound, Compound HBD, in protecting isolated LDL from oxidation as well as foam cells formation. Moreover, the glutathione peroxidase (GPx)-like activity of Compound HBD was analyzed in order to explore the mechanisms related to the above-mentioned protective effects. The Compound HBD in a concentration-dependent manner... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atherosclerosis; Compound HBD; Foam cell; GPx-like activity; LDL oxidation; Organoselenium compounds. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501953 |
| |
|
|
| Meinerz,D.F.; de Paula,M.T.; Comparsi,B.; Silva,M.U.; Schmitz,A.E.; Braga,H.C.; Taube,P.S.; Braga,A.L.; Rocha,J.B.T.; Dafre,A.L.; Farina,M.; Franco,J.L.; Posser,T.. |
| We evaluated the potential neuroprotective effect of 1-100 µM of four organoselenium compounds: diphenyl diselenide, 3’3-ditri-fluoromethyldiphenyl diselenide, p-methoxy-diphenyl diselenide, and p-chloro-diphenyl diselenide, against methylmercury-induced mitochondrial dysfunction and oxidative stress in mitochondrial-enriched fractions from adult Swiss mouse brain. Methylmercury (10-100 µM) significantly decreased mitochondrial activity, assessed by MTT reduction assay, in a dose-dependent manner, which occurred in parallel with increased glutathione oxidation, hydroperoxide formation (xylenol orange assay) and lipid peroxidation end-products (thiobarbituric acid reactive substances, TBARS). The co-incubation with diphenyl diselenide (100 µM) completely... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Methylmercury; Mitochondria; Oxidative stress; Organoselenium compounds; Diphenyl diselenide. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100012 |
| |
|
|
|
