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Relationship between mitochondrial gene rearrangements and stability of the origin of light strand replication Genet. Mol. Biol.
Fonseca,Miguel M.; Harris,D. James.
Mitochondrial gene rearrangements are much more frequent in vertebrates than initially thought. It has been suggested that the origin of light strand replication could have an important role in the process of gene rearrangements, but this hypothesis has never been tested before. We used amphibians to test the correlation between light-strand replication origin thermodynamic stability and the occurrence of gene rearrangements. The two variables were correlated in a non-phylogenetic approach, but when tested in a phylogenetically based comparative method the correlation was not significant, although species with unstable light-strand replication origins were much more likely to have undergone gene rearrangements. This indicates that within amphibians there...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MtDNA replication; Gene rearrangements; Origin of replication; Secondary structure; Amphibians.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300027
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