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| Registros recuperados: 31 | |
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| Zeni,Susana Noemí. |
| La prevalencia de dos desórdenes crónicos como la osteoporosis y la obesidad se encuentra en aumento. La fisiopatología de ambas alteraciones metabólicas es multifactorial e incluye factores genéticos, factores ambientales y hormonales. Diversos estudios clínicos y experimentales demuestran la existencia de una interacción entre el tejido adiposo y el esqueleto, similar a la que ocurre entre las patologías mencionadas. Si bien se pensaba que la obesidad protegía al hueso, actualmente se postula que un exceso de tejido graso, fundamentalmente grasa abdominal, sería un factor de riesgo para el desarrollo de osteoporosis y fracturas por fragilidad. Diversos factores secretados por el tejido graso incrementados por efecto de la obesidad jugarían un rol clave... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hueso; Remodelamiento óseo; Adipocitos; Estrés oxidativo; Obesidad; Osteoporosis. |
| Ano: 2016 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000300006 |
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| Mastaglia,Silvina. |
| La sarcopenia asociada a la edad es una condicion caracterizada por una disminucion de la masa y fuerza muscular de causa multifactorial. El hueso y el musculo son dos tejidos que se encuentran interrelacionados entre si. Las fuerzas mecanicas aplicadas sobre el hueso son aquellas originadas por la contraccion muscular, lo cual condiciona las propiedades del hueso como masa, tamano, forma y arquitectura. Por la tanto, la disminucion de la masa y fuerza muscular conduciran a una disminucion de la cantidad y calidad osea. De esta manera, la sarcopenia es una condicion que en adultos mayores incrementa el riesgo de caidas y fracturas por fragilidad osea, por lo que se propone el termino de osteosarcopenia para identificar aquellos adultos mayores con mayor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteosarcopenia; Osteoporosis; Fracturas. |
| Ano: 2016 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000300004 |
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| LUCINDA,LEDA M.F.; AARESTRUP,BEATRIZ J.V.; REBOREDO,MAYCON M.; PAINS,THAIS D.A.; CHAVES,RAPHAEL Z.; REIS,JOÃO E.P.; LOUZADA,MÁRIO J.Q.; GUERRA,MARTHA O.. |
| ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone density; DEXA scan; Ginkgo biloba; Osteoporosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602833 |
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| Pino,Ana María; Rosen,Clifford J; Rodríguez,J. Pablo. |
| The formation, maintenance, and repair of bone tissue involve close interlinks between two stem cell types housed in the bone marrow: the hematologic stem cell originating osteoclasts and mesenchymal stromal cells (MSCs) generating osteoblasts. In this review, we consider malfunctioning of MSCs as essential for osteoporosis. In osteoporosis, increased bone fragility and susceptibility to fractures result from increased osteoclastogenesis and insufficient osteoblastogenesis. MSCs are the common precursors for both osteoblasts and adipocytes, among other cell types. MSCs' commitment towards either the osteoblast or adipocyte lineages depends on suitable regulatory factors activating lineage-specific transcriptional regulators. In osteoporosis, the reciprocal... |
| Tipo: Journal article |
Palavras-chave: MSCs; Osteoporosis; Adipogenesis; Bone marrow microenvironment. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300009 |
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| Roldan,Eugenia Quiros; Brianese,Nigritella; Raffetti,Elena; Focà,Emanuele; Pezzoli,Maria Chiara; Bonito,Andrea; Ferraresi,Alice; Lanza,Paola; Porcelli,Teresa; Castelli,Francesco. |
| ABSTRACT Introduction: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture. Methods: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound. The assessment of osteoporosis diagnostic accuracy was performed for calcaneal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoporosis; HIV; Calcaneal ultrasound. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600581 |
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| Paiva,A.G.; Yanagihara,G.R.; Macedo,A.P.; Ramos,J.; Issa,J.P.M.; Shimano,A.C.. |
| Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture healing has been investigated in several previous studies because there is still controversy over the effect osteoporosis has on the healing process. The current study aimed to analyze two different periods of bone healing in normal and osteopenic rats. Sixty, 7-week-old female Wistar rats were randomly divided into four groups: unrestricted and immobilized for 2 weeks after osteotomy (OU2), suspended and immobilized for 2 weeks after osteotomy (OS2), unrestricted and immobilized for 6 weeks after osteotomy (OU6), and suspended and immobilized for 6 weeks after osteotomy (OS6). Osteotomy was performed in the middle third of the right tibia 21 days after tail... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoporosis; Osteotomy; Fracture healing; Immobilization; Rats. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300708 |
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| Castro,T.C.M.; Terreri,M.T.; Szejnfeld,V.L.; Castro,C.H.M.; Fisberg,M.; Gabay,M.; Hilário,M.O.E.. |
| We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Systemic lupus erythematosus; Children; Adolescents; Bone mineral density; Osteoporosis; Corticosteroids. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000008 |
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| Lima,C.A.; Lyra,A.C.; Mendes,C.M.C.; Lopes,M.B.; Coqueiro,F.G.; Rocha,R.; Santana,G.O.. |
| Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classification, disease activity and drug therapy were also tested. A cross-sectional prevalence study with a comparison group was conducted. One hundred and twenty-eight patients were evaluated: 68 patients with ulcerative colitis (UC), and 60 with Crohn's disease (CD). The control group consisted of 67 healthy subjects. All patients and controls had BMD measured and in IBD patients, current medications, hospitalization, and disease location, extent and phenotype, according to the Montreal classification, were recorded. Multiple... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone mineral density; Ulcerative colitis; Crohn’s disease; Inflammatory bowel disease; Osteoporosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200614 |
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| Krahe,C.; Friedman,R.; Gross,J.L.. |
| Osteoporosis is a major health problem. Little is known about the risk factors in premenopause. Sixty 40-50-year old patients with regular menses were studied cross-sectionally. None of the patients were on drugs known to interfere with bone mass. Patients answered a dietary inquiry and had their bone mineral density (BMD) measured. The Z scores were used for the comparisons. A blood sample was taken for the determination of FSH, SHBG, estradiol, testosterone, calcium and alkaline phosphatase. Calcium and creatinine were measured in 24-h urine. A Z score less than -1 was observed for the lumbar spine of 14 patients (23.3%), and for the femur of 24 patients (40%). Patients with a Z score less than -1 for the lumbar spine were older than patients with a Z... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoporosis; Bone loss; Premenopause; Osteopenia; Densitometry. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900003 |
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| Barros,E.R.; Kasamatsu,T.S.; Ramalho,A.C.; Hauache,O.M.; Vieira,J.G.H.; Lazaretti-Castro,M.. |
| Osteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: COLIA1; Bone mineral density; Risk factors; Polymorphism; Osteoporosis. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800005 |
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| Ramalho,A.C.; Lazaretti-Castro,M.; Hauache,O.; Kasamatsu,T.; Brandão,C.; Reis,A.F.; Takata,E.; Cafalli,F.; Tavares,F.; Gimeno,S.G.A.; Vieira,J.G.H.. |
| Fractures are the feared consequences of osteoporosis and fractures of the proximal femur (FPF) are those that involve the highest morbidity and mortality. Thus far, evaluation of bone mineral density (BMD) is the best way to determine the risk of fracture. Genetic inheritance, in turn, is one of the major determinants of BMD. A correlation between different genotypes of the vitamin D receptor (VDR) and BMD has been recently reported. On this basis, we decided to determine the importance of the determination of VDR genotype in the presence of an osteoporotic FPF in a Brazilian population. We studied three groups: group I consisted of 73 elderly subjects older than 65 years (78.5 ± 7.2 years) hospitalized for nonpathological FPF; group II consisted of 50... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoporosis; Fracture of proximal femur (FPF); Vitamin D receptor polymorphism. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700006 |
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| Registros recuperados: 31 | |
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