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	Provedor de dados BJMBR (1) Autor Chen,Guofang (1) Dai,Jinhua (1) Liao,Yufeng (1) Luo,Xianhai (1) Ma,Jianbo (1) Palavra-chave Apoptosis (1) Autophagy (1) MEK/ERK pathway (1) Myocardial infarction (1) PI3K/AKT/mTOR pathway (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5 BJMBR Dai,Jinhua; Ma,Jianbo; Liao,Yufeng; Luo,Xianhai; Chen,Guofang. Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI) by inducing DGCR5. CCK-8 assay was performed to detect the viability of H9c2 cells. Flow cytometry was utilized to test apoptosis of H9c2 cells. These results determined the optimal concentration and effect time of hypoxia as well as PD. Si-DGCR5 was transfected into cells and the expression level was determined by qRT-PCR. Western blot was utilized to evaluate the expression of apoptosis-related... Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction; Apoptosis; Autophagy; PI3K/AKT/mTOR pathway; MEK/ERK pathway. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001200613 Registros recuperados: 1 Primeira ... 1 ... Última

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