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HCV virological response during treatment of chronic hepatitis C is associated with liver histological Improvement in patients with HCV/HIV co-infection BJID
Castro,Gleusa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sérgio; Martinelli,Ana de Lourdes Candolo; Figueiredo,José Fernando de Castro.
Liver histological improvement after treatment for chronic hepatitis C in patients co-infected with human immunodeficiency virus-1 (HIV-1) has been described. Paired liver biopsies in twenty six HCV/HIV co-infected patients were compared to determine factors possibly associated with histological improvement. The patients were submitted to a liver biopsy before treatment for hepatitis C and 25 months after the end of treatment. Fragments of the liver biopsy obtained before and after treatment were compared regarding the following parameters: histological activity index (HAI) and degree of fibrosis (Knodell); intensity of collagen deposits (Sirius Red staining) and degree of stellate cell activation (alpha-smooth muscle actin labeling). The ratios of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic hepatitis C; Hepatic stellate cell; Histological response; Human immunodeficiency virus; Paired liver biopsies.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300004
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