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| Pinto,Claudinéia Aparecida Sales de Oliveira; Lopes,Patricia Santos; Sarruf,Fernanda Daud; Polakiewicz,Bronislaw; Kaneko,Telma Mary; Baby,Andre Rolim; Velasco,Maria Valéria Robles. |
| Papain is an enzyme used in topical formulations as a proteolytic debriding agent for the treatment of open, extensive wounds and burnings. It is also employed as an enhancer for cutaneous permeation of active compounds, chemical peeling and as a progressive depilatory agent. The stability of formulations containing enzymes is not easy. In this research, papain was modified with polyethylene glycol in order to increase the stability of the formulations. The comparative Normal Stability Testing of the topical formulations containing unmodified and modified papain showed that the modified variety presented with a differentiated profile under the adopted temperature conditions (5.0 ± 1.0 °C; 22.0 ± 2.0 °C; 40.0 ± 2.0 °C). The most suitable condition for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Papain/use in topical formulations; Papain/normal stability test; Poliethylene glycol/use; Topical formulations/development; Papain/enzimatic activity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400012 |
