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Development and evaluation of a hot-melt coating technique for enteric coating 60
Patil,Arun Trambak; Khobragade,Deepak Shamrao; Chafle,Sandip Annaji; Ujjainkar,Amol Prasadrao; Umathe,Sudhir Niranjanrao; Lakhotia,Champalal Laxminarayan.
Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric hot-melt coating materials. HMC was carried out in a specially modified coating pan by applying SA and PA in molten state onto preheated pellets...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pellets/coating; Pellets/evaluation; Enteric coating/evaluation; Hot-melt coating/evaluation; Disintegration pH; Diclofenac sodium/pellets; Diclofenac sodium/coating; Palmitic acid/pellets; Palmitic acid/coating; Stearic acid/pellets; Stearic acid/coating.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100008
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Formulation and evaluation of taste mask pellets of granisetron hydrochloride as oro dispersible tablet 60
Choudhary,Nilesh; Avari,Jasmine.
Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest compliance of the patients, especially the geriatrics and pediatrics. In addition, patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders prefer these medications because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. However, the requirements of formulating these dosage forms with mechanical strength sufficient to withstand the rigors of handling and capable of disintegrating within a few seconds on contact with saliva are inextricable. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Granisetron hydrochloride/taste masking; Oro Dispersible Tablet (ODT); Pellets/coating; Oral drugs/delivery system.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300569
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