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| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; GRAFOVA,Iryna; NAIFF,Maricleide de Farias; AVELLA,Maurizio; GENTILE,Gennaro; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Topical formulations; Experimental treatment; Pentamidine isethionate; Animal model; Leishmania. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000100039 |
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