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	Provedor de dados BJMBR (4) Autor Brandão,M.L. (1) Gomes,K.S. (1) Graeff,F.G. (1) Guimarães,F.S. (1) Miguel,T.T. (1) Molchanov,M.L. (1) Nunes-de-Souza,R.L. (1) Vianna,D.M.L. (1) Mais... Palavra-chave Periaqueductal gray (4) Animal model (1) Antinociception (1) Corticotropin-releasing factor (1) Defense behavior (1) Defense reaction (1) Defensive behavior (1) Escape (1) Fear (1) Freezing (1) Metabotropic glutamate receptors (1) Mice (1) Nitric oxide (1) Open-field (1) Opioids (1) Panic (1) Periaqueductal gray columns (1) Rats (1) Serotonin (1) T-ACPD (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2012 (2) 2003 (1) 1999 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray BJMBR Graeff,F.G.. Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal threats and of sympathomotor control areas of the rostral ventrolateral medulla that generate most of the neurovegetative symptoms of the panic attack. The second suggests that endogenous opioids buffer normal subjects from the behavioral and physiological manifestations of the panic attack, and their deficit brings about heightened suffocation sensitivity and separation anxiety in panic patients, making... Tipo: Info:eu-repo/semantics/article Palavras-chave: Panic; Animal model; Periaqueductal gray; Serotonin; Opioids. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400011 Contrasting effects of nitric oxide and corticotropin- releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice BJMBR Miguel,T.T.; Gomes,K.S.; Nunes-de-Souza,R.L.. The anxiogenic and antinociceptive effects produced by glutamate N-methyl-D-aspartate receptor activation within the dorsal periaqueductal gray (dPAG) matter have been related to nitric oxide (NO) production, since injection of NO synthase (NOS) inhibitors reverses these effects. dPAG corticotropin-releasing factor receptor (CRFr) activation also induces anxiety-like behavior and antinociception, which, in turn, are selectively blocked by local infusion of the CRF type 1 receptor (CRFr1) antagonist, NBI 27914 [5-chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine]. Here, we determined whether i) the blockade of the dPAG by CRFr1 attenuates the anxiogenic/antinociceptive effects induced by local infusion of the NO... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Corticotropin-releasing factor; Periaqueductal gray; Defensive behavior; Antinociception; Mice. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400003 Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats BJMBR Molchanov,M.L.; Guimarães,F.S.. The behavioral effects of trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9% (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P<0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P<0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a... Tipo: Info:eu-repo/semantics/other Palavras-chave: Periaqueductal gray; Metabotropic glutamate receptors; Defense behavior; T-ACPD; Open-field; Rats. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200013 Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear BJMBR Vianna,D.M.L.; Brandão,M.L.. The periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from lesion and stimulation studies have not correlated perfectly. After using a strategy that combined both techniques and a reevaluation of the available literature on PAG function and connections, we propose here that freezing could be mediated by different PAG subdivisions depending on the presence of immediate danger or exposure to related signaling cues. These subdivisions are separate functional entities with distinct descending and ascending connections that are likely to play a role in different... Tipo: Info:eu-repo/semantics/article Palavras-chave: Periaqueductal gray; Defense reaction; Fear; Escape; Freezing; Periaqueductal gray columns. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500002 Registros recuperados: 4 Primeira ... 1 ... Última

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