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Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action 116
WONG,Kah-Hui; KANAGASABAPATHY,Gowri; BAKAR,Robiah; PHAN,Chia-Wei; SABARATNAM,Vikineswary.
Abstract Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. We investigated the ability of polysaccharide from Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats by daily oral administration. In sensory functional recovery test, the time taken for the rats to withdraw its hind limb from contact with the hot plate was measured. The test revealed acceleration of sensory recovery in the polysaccharide group compared to negative controls. Further, peripheral nerve injury leads to changes at the remotely located DRG containing cell bodies of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hericium erinaceus; Polysaccharide; Peripheral nerve regeneration; Sensory functional recovery; Protein kinases; Blood-nerve barrier.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612015000400712
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