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	Provedor de dados BJPS (2) Autor Basavaiah,Kanakapura (2) Hiriyanna,Salmara Ganeshbhat (1) Rajedraprasad,Nagaraju (1) Rajendraprasad,Nagaraju (1) Tharpa,Kalsang (1) Vinay,Kanakapura Basavaiah (1) Mais... Palavra-chave Permanganate (2) Spectrophotometry (2) Olanzapine/determination (1) Pharmaceutical products (1) Pharmaceuticals (1) Simvastatin assay (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Sensitive spectrophotometric assay of simvastatin in pharmaceuticals using permanganate BJPS Tharpa,Kalsang; Basavaiah,Kanakapura; Rajedraprasad,Nagaraju; Vinay,Kanakapura Basavaiah; Hiriyanna,Salmara Ganeshbhat. Two simple, sensitive, selective and inexpensive spectrophotometric methods are described for the determination of simvastatin (SMT) in bulk drug and in tablets using permanganate as the oxidimetric reagent. In method A, SMT is treated with a measured excess of permanganate in acetic acid medium and the unreacted oxidant is measured at 550 nm, whereas in method B the reaction is carried out in alkaline medium and the resulting manganate is measured at 610 nm. In method A, the amount of permanganate reacted corresponds to the SMT content and the absorbance is found to decrease linearly with the concentration; and in method B, the absorbance increases with concentration. The working conditions of assays were optimized, and the methods were validated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Simvastatin assay; Spectrophotometry; Permanganate; Pharmaceutical products. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100010 Determination of olanzapine by spectrophotometry using permanganate BJPS Rajendraprasad,Nagaraju; Basavaiah,Kanakapura. Two new spectrophotometric methods using permanganate as the oxidimetric reagent for the determination of olanzapine (OLP) were developed and validated as per the current ICH guidelines. The methods involved the addition of known excess of permanganate to OLP in either acid or alkaline medium followed by the determination of unreacted permanganate at 550 nm (method A) or bluish-green color of manganate at 610 nm (method B). The decrease in absorbance in method A or increase in absorbance in method B as a function of concentration of OLP was measured and related to OLP concentration. Under optimized conditions, Beer's law was obeyed over the ranges 2.0 to 20 and 1.0 to 10 μg mL-1 in method A and method B, respectively. The calculated molar absorptivity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Olanzapine/determination; Spectrophotometry; Permanganate; Pharmaceuticals. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300020 Registros recuperados: 2 Primeira ... 1 ... Última

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