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Oxidative stress may explain how hypertension is maintained by normal levels of angiotensin II BJMBR
Romero,J.C.; Reckelhoff,J.F..
It is well known that essential hypertension evolves in most patients with "near normal" levels of plasma renin activity. However, these levels appear to be responsible for the high levels of arterial pressure because they are normalized by the administration of angiotensin II converting inhibitors or angiotensin receptor antagonist. In experimental animals, hypertension can be induced by the continuous intravenous infusion of small doses of angiotensin II that are not sufficient to evoke an immediate pressor response. However, this condition resembles the characteristics of essential hypertension because the high levels of blood pressure exist with normal plasma levels of angiotensin II. It is suggested that small amounts of angiotensin whose plasma...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Isoprostanes; Peroxynitrites; Essential hypertension.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600006
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