Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Arq. Bras. Med. Vet. Zootec. (2) BJPS (1) Autor Ahmed,Saeed (1) Boggio,J.C. (1) Diaz David,D.C. (1) Encinas,T. (1) Huang,Guihua (1) Li,Xianqiang (1) Liu,Yonghong (1) Picco,E.J. (1) Rubio,M.R. (1) Tian,Liu (1) Wang,Longmei (1) Wang,Yanping (1) Yang,Zhenlei (1) Zhang,Ling (1) Zhang,Xiuping (1) Mais... Palavra-chave Pharmacokinetic (3) Anesthetic agent (1) Bronchoaveolar lavage (1) Calf (1) Florfenicol (1) In vitro release (1) Micromeritic (1) Microspheres (1) PLGA (1) Pre-ruminant (1) Pulmonary (1) Pulmonary administration (1) Pulmonary arterial hypertension (1) Sodium meclofenamate (1) Tadalafil (1) Tissue distribution (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2019 (1) 2018 (1) 2004 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle Arq. Bras. Med. Vet. Zootec. Picco,E.J.; Diaz David,D.C.; Encinas,T.; Rubio,M.R.; Boggio,J.C.. The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscular administration to calves were characterised by a rapid distribution phase (t½alpha ), 15.45± 4.85min and 23.14± 7.24min for the intravenous and intramuscular administration, respectively, followed by a longer elimination phase (t½beta ) after intramuscular treatment (17.55± 6.52h.). The apparent volume of distribution (Vd) of the drug after intravenous... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calf; Sodium meclofenamate; Pharmacokinetic; Pre-ruminant. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600001 Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics Arq. Bras. Med. Vet. Zootec. Wang,Yanping; Zhang,Ling; Ahmed,Saeed; Liu,Yonghong; Li,Xianqiang. ABSTRACT The primary objective of the current study was to compare the pharmacokinetic (PK) of florfenicol (FFL) in pulmonary epithelial lining fluid and the plasma in swine. The second objectives were to evaluate the effect of anesthesia with ketamine and propofol on the PK of FFL in plasma. Bronchoaveolar lavage was utilized for quantification of PELF volume and the urea dilution method was used to determine the concentration of FFL in PELF. FFL was administered intramuscularly (IM) to swine in a single dose of 20mg/kg body weight. The main PK parameters of FFL in plasma and PELF were as follows: the area under the concentration-time curve, maximal drug concentration, elimination half-life and mean residence time were 69.45±4.36 vs 85.03±9.26μg·hr/ml,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthetic agent; Bronchoaveolar lavage; Florfenicol; Pharmacokinetic; Pulmonary. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000501497 Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation BJPS Yang,Zhenlei; Wang,Longmei; Tian,Liu; Zhang,Xiuping; Huang,Guihua. Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegradable PLGA (poly(lactic-co-glycolic acid)) microspheres (TDF-PLGA-MS) via emulsification-solvent evaporation. The resulting microspheres were processed into pulmonary inhalant by freeze drying. The TDF-PLGA-MS was spherical and uniform, with an average particle diameter ~10.29 µm. The encapsulation efficiency and drug loading yield of TDF-PLGA-MS were 81.68% and 8.52%, respectively. The investigation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pulmonary arterial hypertension; Tadalafil; PLGA; Microspheres; Pulmonary administration; Micromeritic; In vitro release; Pharmacokinetic; Tissue distribution. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100587 Registros recuperados: 3 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco