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Plasma metanephrines: a novel and cost-effective test for pheochromocytoma BJMBR
Eisenhofer,G.; Walther,M.; Keiser,H.R.; Lenders,J.W.M.; Friberg,P.; Pacak,K..
Pheochromocytomas are rare chromaffin cell tumors that nevertheless must be excluded in large numbers of patients who develop sustained or episodic hypertension as well as in many others with suggestive symptoms or with a familial history of pheochromocytoma. Diagnosis of pheochromocytoma depends importantly on biochemical evidence of excess catecholamine production by a tumor. Imperfect sensitivity and specificity of commonly available biochemical tests and the low incidence of the tumor among the tested population mean that considerable time and effort can be expended in confirming or ruling out pheochromocytoma in patients where the tumor is suspected. Measurements of plasma free metanephrines provide a superior test compared to other available tests...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pheochromocytoma; Hypertension; Sympathetic nervous system; Adrenal gland; Metanephrines; Catecholamines.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000005
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