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	Provedor de dados BJMBR (2) Autor Arzt,E. (1) Braga,P.B.S. (1) Bronstein,M.D. (1) Corrêa-Giannella,M.L.C. (1) Fortes,M.A.H.Z. (1) Giorgi,R.R. (1) Kuchenbauer,F. (1) Murat,C.B. (1) Paez-Pereda,M. (1) Stalla,G.K. (1) Mais... Palavra-chave Pituitary adenomas (2) Cell proliferation (1) Extracellular matrix (1) Genomic amplification (1) Integrins (1) PIK3CA proto-oncogene (1) Pituitary gland (1) Pituitary hormones (1) Somatic mutation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas BJMBR Murat,C.B.; Braga,P.B.S.; Fortes,M.A.H.Z.; Bronstein,M.D.; Corrêa-Giannella,M.L.C.; Giorgi,R.R.. The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pituitary adenomas; PIK3CA proto-oncogene; Genomic amplification; Somatic mutation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009 Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix BJMBR Paez-Pereda,M.; Kuchenbauer,F.; Arzt,E.; Stalla,G.K.. The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival. The extracellular matrix conveys signals through membrane receptors called integrins and plays an important role in pituitary physiology and tumorigenesis. There is a differential expression of extracellular matrix components and integrins during the pituitary development in the embryo and during tumorigenesis in the adult. Different extracellular matrix components regulate adrenocorticotropin at the level of the proopiomelanocortin gene transcription. The extracellular matrix also controls the proliferation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Extracellular matrix; Integrins; Pituitary gland; Pituitary adenomas; Pituitary hormones; Cell proliferation. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000005 Registros recuperados: 2 Primeira ... 1 ... Última

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