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| SEROV,OLEG; MATVEEVA,NATALIA; KUZNETSOV,SERGEY; KAFTANOVSKAYA,ELENA; MITTMANN,JOSANE. |
| The properties of embryonic hybrid cells obtained by fusion of embryonic stem (ES) or teratocarcinoma (TC) cells with differentiated cells are reviewed. Usually, ES-somatic or TC-somatic hybrids retain pluripotent capacity at high levels quite comparable or nearly identical with those of the pluripotent partner. When cultured in vitro, ES-somatic- and TC-somatic hybrid cell clones, as a rule, lose the chromosomes derived from the somatic partner; however, in some clones the autosomes from the ES cell partner were also eliminated, i.e. the parental chromosomes segregated bilaterally in the ES-somatic cell hybrids. This opens up ways for searching correlation between the pluripotent status of the hybrid cells and chromosome segregation patterns and therefore... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ES cells; EG cells; Hybrid cells; Pluripotency; Reprogramming. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000400009 |
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| Monti,Manuela; Perotti,Cesare; Del Fante,Claudia; Cervio,Marila; Redi,Carlo Alberto. |
| The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asymmetric division) are evaluated in the light of the niche hypothesis for the stemness state. The induction of cell pluripotency and the different stem cells sources are presented (embryonic, adult and cord blood). We highlight the embryonic and adult stem cell properties and possible therapies while we emphasize the particular scientific and social values of cord blood donation to set up cord blood banks. The current scientific and legal... |
| Tipo: Journal article |
Palavras-chave: Embryonic stem cell; Adult stem cell; Pluripotency; Induced pluripotent stem cells; Umbilical cord blood; Spinal cord stroke; Parkinson' disease. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300002 |
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