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Martins,V.R.. |
Prions are an unconventional form of infectious agents composed only of protein and involved in transmissible spongiform encephalopathies in humans and animals. The infectious particle is composed by PrPsc which is an isoform of a normal cellular glycosyl-phosphatidylinositol (GPI) anchored protein, PrPc, of unknown function. The two proteins differ only in conformation, PrPc is composed of 40% <FONT FACE="Symbol">a</FONT> helix while PrPsc has 60% ß-sheet and 20% <FONT FACE="Symbol">a</FONT> helix structure. The infection mechanism is trigged by interaction of PrPsc with cellular prion protein causing conversion of the latter's conformation. Therefore, the infection spreads because new PrPsc molecules are generated exponentially... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prion; Transmissible spongiform encephalopathies; PrPc; Receptor. |
Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700009 |
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