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	Provedor de dados Genet. Mol. Biol. (1) Autor Valenzuela,Carlos Y (1) Palavra-chave Bose-Einstein distribution (1) HIV-1 (1) Non-random evolution (1) Non-random sequences (1) Pre-transcriptional evolution (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2009 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Non-random pre-transcriptional evolution in HIV-1: a refutation of the foundational conditions for neutral evolution Genet. Mol. Biol. Valenzuela,Carlos Y. The complete base sequence of HIV-1 virus and GP120 ENV gene were analyzed to establish their distance to the expected neutral random sequence. An especial methodology was devised to achieve this aim. Analyses included: a) proportion of dinucleotides (signatures); b) homogeneity in the distribution of dinucleotides and bases (isochores) by dividing both segments in ten and three sub-segments, respectively; c) probability of runs of bases and No-bases according to the Bose-Einstein distribution. The analyses showed a huge deviation from the random distribution expected from neutral evolution and neutral-neighbor influence of nucleotide sites. The most significant result is the tremendous lack of CG dinucleotides (p < 10-50), a selective trait of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Non-random evolution; HIV-1; Bose-Einstein distribution; Pre-transcriptional evolution; Non-random sequences. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100025 Registros recuperados: 1 Primeira ... 1 ... Última

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