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| Carvalho,Fabiana Rabe; Cosendey,Rachel Ingrid Juliboni; Souza,Cintia Fernandes; Medeiros,Thalia; Menezes,Paulo Alexandre; Silva,Andrea Alice; Almeida,Jorge Reis; Lugon,Jocemir Ronaldo. |
| Abstract Introduction: Human cytomegalovirus is a major cause of morbidity in kidney transplant patients. Objectives: We aimed to study viral replication and serological response in the first months post kidney transplant in patients undergoing universal prophylaxis or preemptive therapy and correlate the findings with the clinical course of Human cytomegalovirus infection. Patients and methods: Independent from the clinical strategy adopted for managing Human cytomegalovirus infection, prophylaxis versus preemptive therapy, the pp65 antigenemia assay and serological response were assessed on the day of transplantation, and then weekly during the first three months of post-transplant. Results: From the 32 transplant recipients, 16 were positive for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cytomegalovirus; Pp65 antigenemia; Kidney transplant; Universal prophylaxis; Preemptive therapy. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100051 |
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| Pinto,Cahue Henrique; Tedesco-Silva Jr,Helio; Felipe,Claudia Rosso; Ferreira,Alexandra Nicolau; Cristelli,Marina; Viana,Laila Almeida; Aguiar,Wilson; Medina-Pestana,José. |
| ABSTRACT Background: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and the associated costs. This study investigated the efficacy and safety of targeted preemptive therapy according to perceived risk of cytomegalovirus infection after kidney transplantation. Methods: 144 adult kidney transplant recipients were enrolled in this 12-month study. None received cytomegalovirus pharmacological prophylaxis. Only high risk patients (positive donor/negative recipient (D+/R−), use of induction therapy with antithymocyte globulin, treatment of rejection) received preemptive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cytomegalovirus; Kidney; Transplant; Preemptive therapy. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600576 |
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