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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor AGUAYO,FRANCISCO R (1) AKIBA,SUMINORI (1) CASTILLO,DARWINS (1) CORVALAN,ALEJANDRO (1) Cabral,D.F. (1) Carvalho-Salles,A.B. (1) EIZURU,YOSHITO (1) GUZMAN,LEDA M (1) Hackel,C. (1) KORIYAMA,CHIHAYA (1) Mesquita,J.C. (1) Ribeiro,M.L. (1) Santos,A. (1) Mais... Palavra-chave Promoter region (2) 5'Untranslated region (1) DNA sequence alterations (1) Human androgen receptor gene (1) Lung carcinoma (1) Methylation (1) Prostate cancer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2007 (1) 2004 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile Biol. Res. GUZMAN,LEDA M; KORIYAMA,CHIHAYA; AKIBA,SUMINORI; EIZURU,YOSHITO; CASTILLO,DARWINS; CORVALAN,ALEJANDRO; AGUAYO,FRANCISCO R. The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7% (59/74). When we considered histological type, we observed that p16 promoter methylation... Tipo: Journal article Palavras-chave: Lung carcinoma; Methylation; Promoter region. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400011 Rarity of DNA sequence alterations in the promoter region of the human androgen receptor gene BJMBR Cabral,D.F.; Santos,A.; Ribeiro,M.L.; Mesquita,J.C.; Carvalho-Salles,A.B.; Hackel,C.. The human androgen receptor (AR) gene promoter lies in a GC-rich region containing two principal sites of transcription initiation and a putative Sp1 protein-binding site, without typical "TATA" and "CAAT" boxes. It has been suggested that mutations within the 5'untranslated region (5'UTR) may contribute to the development of prostate cancer by changing the rates of gene transcription and/or translation. In order to investigate this question, the aim of the present study was to search for the presence of mutations or polymorphisms at the AR-5'UTR in 92 prostate cancer patients, where histological diagnosis of adenocarcinoma was established in specimens obtained from transurethral resection or after prostatectomy. The AR-5'UTR was amplified by PCR from... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human androgen receptor gene; Promoter region; Prostate cancer; 5'Untranslated region; DNA sequence alterations. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200004 Registros recuperados: 2 Primeira ... 1 ... Última

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