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Interference of propylene glycol with the hole-board test BJMBR
Lourenço da Silva,A.; Elisabetsky,E..
Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the head-dipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Screening; Anxiolytic drugs; Propylene glycol; Diazepam; Solvents; Hole-board.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400016
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Supplementation of dairy cows with propylene glycol during the periparturient period: effects on body condition score, milk yield, first estrus post-partum, beta-hydroxybutyrate, non-esterified fatty acids and glucose concentrations Ciência Rural
Fonseca,Luís Fernando Laranja da; Rodrigues,Paulo Henrique Mazza; Santos,Marcos Veiga dos; Lima,André Pinto; Lucci,Carlos de Sousa.
The objective of this study was to analyse the effects of propylene glycol (PPG) supplementation to periparturient cows on: milk yield, changes in body condition score (BCS), days to first oestrus after calving, and on the beta-hydroxybutyrate (BHBA), non-esterefied fatty acids (NEFA) and glucose concentrations. Twenty-three Holstein cows were distributed into two treatments: a) 300 mL of PPG (group treatment, 11 cows), b) 300 mL of water (group control, 12 cows), administered via drench in periparturient period. BCS was evaluated on days -10, 0, 15, 30, 45 and 60 relative to calving date. There was no effect of treatment or time on milk yield, although the interaction of time*treatment was significant and during the 4th and 5th week of lactation, milk...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dairy cow; Propylene glycol; Milk yield; Body condition score; Reproductive performance.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782004000300037
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Gluconeogenic supplements do not affect production, reproductive traits and blood metabolite of holstein cows during the transition period Scientia Agricola
Oliveira,Paulo Garcez de; Pires,Alexandre Vaz; Meyer,Paula Marques; Susin,Ivanete; Villarreta,Elias Tunon; Rodrigues,Paulo Henrique Mazza; Santos,Flávio Augusto Portella.
The use of gluconeogenic supplements for dairy cows during the transition period has produced contradictory responses in the literature, making it difficult to recommend them. The objective of this trial was to evaluate supplementation with propylene glycol (PG), calcium propionate (CP), and "Dairy Power Drench®" (DR) on the transitional period of Holstein cows. Parameters studied were variation of body condition score (BCS), body weight (BW), milk production (MP), reproductive efficiency and nonesterified fatty acid concentration (NEFA). One hundred and sixty five animals from two commercial herds were used. Treatments consisted of: C- Control; DR- administration of "Dairy Power Drench®" (3 applications) during postpartum; CP- daily administration of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propylene glycol; Calcium propionate; Dairy power drench; Holstein cow; Reproductive efficiency.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162004000400005
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Plasticizer types and whey protein coatings on internal quality and shelf life of eggs stored for 42 days Scientia Agricola
Pires,Paula Gabriela da Silva; Franceschi,Carolina Haubert; Bavaresco,Caroline; Leuven,Aline Fernanda Rodrigues; Andretta,Ines.
ABSTRACT: Effects of plasticizer types and whey protein concentrate (WPC) as coatings were evaluated on internal quality and shelf life of eggs stored for 42 days. Eggs were coated with WPC at 8 % solution combined with the plasticizers glycerol (GLY), sorbitol (SOR), and propylene glycol (PRO). The eggs were stored at 20 °C. Weight loss, Haugh Unit (HU), albumen and yolk pH, and yolk index (YI) were evaluated weekly from day 0 to 42 days. After, electron microscopy of the eggshell structure was performed. The data was submitted to the analysis of variance and the effects of treatment, storage time, and the interaction between these factors were evaluated. There was significant interaction between factors (treatment and periods) for weight loss (p <...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Egg quality; Glycerol; Propylene glycol; Sorbitol.
Ano: 2021 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162021000700901
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