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| SALVATIERRA,CRISTIANA S.B.; REIS,SÍLVIA R.L.; PESSOA,ANA F.M.; SOUZA,LETÍCIA M.I. DE; STOPPIGLIA,LUIZ F.; VELOSO,ROBERTO V.; REIS,MARISE A.B.; CARNEIRO,EVERARDO M.; BOSCHERO,ANTONIO C.; COLODEL,EDSON M.; ARANTES,VANESSA C.; LATORRACA,MÁRCIA Q.. |
| The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. As controls, adult pregnant and non-pregnant rats were fed a normal-protein diet (17%). Pregnant and non-pregnant rats in the experimental groups were fed a low-protein diet (6%) for 15 days. Low protein diet during pregnancy increased serum prolactin level, reduced serum corticosterone concentration and the expression of both protein kinase B/AKT1 (AKT1) and p70 ribosomal protein S6... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MAP kinase pathway; Pancreatic islets; PI3K pathway; Pregnancy; Protein restriction; Rats. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201007 |
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| Jeronimo,L. C; Confortim,H. D; Centenaro,L. A; Brancalhão,R. M. C; Pinheiro,P. F. F; Matheus,S. M. M; Torrejais,M. M. |
| Protein restriction implies the functional involvement of several systems and organs, including the skeletal muscle, because it is a protein reservoir in the body. This study sought to analyze the morphological and morphometric features of the muscle fibers and neuromuscular junctions (NMJs) of the extensor digitorum longus (EDL) muscle in rats at 365 days of age, submitted to maternal protein restriction during the gestation and lactation periods. Wistar rats were divided into two groups: a Control Group - mothers fed a normal-protein diet (17 % protein) during pregnancy and lactation; and a Restricted Group - mothers fed a low-protein diet (6 % protein) during pregnancy and lactation. The pups were kept with the mother throughout the lactation period (21... |
| Tipo: Journal article |
Palavras-chave: Morphology; Morphometry; Protein restriction; Extensor digitorum longus muscle; Rat. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100057 |
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