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| Registros recuperados: 13 | |
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| COURT,FELIPE A; ÁLVAREZ,JAIME. |
| In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis. |
| Tipo: Journal article |
Palavras-chave: Axon; Protein synthesis; Nerve regeneration; Schwann cell; Wld s. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009 |
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| Trentin,A.G.; Alvarez-Silva,M.. |
| Thyroid hormone (T3) is essential to normal brain development. Previously, we have shown that T3 induces cerebellar astrocyte proliferation. This effect is accompanied by alteration in glial fibrillary acidic protein (GFAP) and fibronectin organization. In the present study, we report that the C6 glioma cell line, which expresses GFAP and is classified as an undifferentiated astrocytic cell type, is a target for T3 action. The C6 monolayers were treated with 50 nM T3 for 3 days, after which the cells were maintained for 2 days without medium changes. In C6 cells, T3 induced the expression of proteins of 107, 73 and 62 kDa. The hormone also up-regulated protein bands of 100 (+50%), 37 (+50%) and 25.5 kDa (+50%) and down-regulated proteins of 94 (-100%),... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Thyroid hormone; Glioma; Protein synthesis; GFAP; Vimentin; Differentiation. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000008 |
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| Villas-Bôas,C.S.A.; Conceição,T.M.; Ramírez,J.; Santoro,A.B.M.; Da Poian,A.T.; Montero-Lomelí,M.. |
| Dengue virus (DV)-induced changes in the host cell protein synthesis machinery are not well understood. We investigated the transcriptional changes related to initiation of protein synthesis. The human hepatoma cell line, HepG2, was infected with DV serotype 2 for 1 h at a multiplicity of infection of one. RNA was extracted after 6, 24 and 48 h. Microarray results showed that 36.5% of the translation factors related to initiation of protein synthesis had significant differential expression (Z-score ≥ ±2.0). Confirmation was obtained by quantitative real-time reverse transcription-PCR. Of the genes involved in the activation of mRNA for cap-dependent translation (eIF4 factors), eIF4A, eIF4G1 and eIF4B were up-regulated while the negative regulator of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dengue virus; Flavivirus; Protein synthesis. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100004 |
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| Marzuca-Nassr,G.N.; Fortes,M.A.S.; Guimarães-Ferreira,L.; Murata,G.M.; Vitzel,K.F.; Vasconcelos,D.A.A.; Bassit,R.A.; Curi,R.. |
| The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitantly for 5 days. Body weight, soleus and EDL muscle masses, and cross-sectional areas (CSA) of the muscle fibers were measured. Signaling pathways associated with skeletal muscle mass regulation (FST, MSTN, FAK, IGF-1, MGF, Akt, mTOR, atrogin-1, and MuRF1 expressions, and Akt, S6, GSK3B, and 4EBP1 proteins) were evaluated in the muscles. Soleus muscle exhibited more atrophy than the EDL muscle due to HS. Creatine supplementation attenuated the decrease of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Creatine supplementation; Hindlimb suspension; Muscle disuse atrophy; Protein synthesis; Protein degradation. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000606 |
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| Щербань, С. А.. |
| Results of the comparative investidation of protein synthesis levels in gills, hepatopancreas, legs and somatic tissues of different age–size groups of mussels Anadara inaeguivalvis Br. (normal condition) and under nutrition stress are present. It was shown the protein synthesis process have the expressed tissue pecilitiry, differences of synthesis levels were observed for somatic tissues only. Biosynthesis process in anadara tissues were charactirised by different directions under the nutrition stress. Thus, the tendency of biosynthesis levels increase or decrease in gills was absent; the synthesis level in legs tissues in 1,3 times decreased. |
| Tipo: Book Section |
Palavras-chave: Anadara inaeguivalvis; Protein synthesis; Tissue features; RNK; Index RNK/DNA; Deficit food. |
| Ano: 2010 |
URL: http://repository.ibss.org.ua/dspace/handle/99011/1884 |
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| Geyer, Kathrin K.; Munshi, Sabrina E.; Vickers, Martin; Squance, Michael; Wilkinson, Toby J.; Berrar, Daniel; Chaparro, Cristian; Swain, Martin T.; Hoffmann, Karl F.. |
| Uncontrolled host immunological reactions directed against tissue-trapped eggs precipitate a potentially lethal, pathological cascade responsible for schistosomiasis. Blocking schistosome egg production, therefore, presents a strategy for simultaneously reducing immunopathology as well as limiting disease transmission in endemic or emerging areas. We recently demonstrated that the ribonucleoside analogue 5-azacytidine (5-AzaC) inhibited Schistosoma mansoni oviposition, egg maturation and ovarian development. While these anti-fecundity effects were associated with a loss of DNA methylation, other molecular processes affected by 5-AzaC were not examined at the time. By comparing the transcriptomes of 5-AzaC-treated females to controls, we provide evidence... |
| Tipo: Text |
Palavras-chave: Schistosoma mansoni; Epigenetics; 5-Azacytidine; Fecundity; RNA-Seq; Protein synthesis; Stem cells. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00615/72703/71747.pdf |
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| Registros recuperados: 13 | |
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