|
|
|
|
|
| Cui,S.Q.; Wang,Q.; Zheng,Y.; Xiao,B.; Sun,H.W.; Gu,X.L.; Zhang,Y.C.; Fu,C.H.; Dong,P.X.; Wang,X.M.. |
| We evaluated the effect of puerarin on spatial learning and memory ability of mice with chronic alcohol poisoning. A total of 30 male C57BL/6 mice were randomly divided into model, puerarin, and control groups (n=10 each). The model group received 60% (v/v) ethanol by intragastric administration followed by intraperitoneal injection of normal saline 30 min later. The puerarin group received intragastric 60% ethanol followed by intraperitoneal puerarin 30 min later, and the control group received intragastric saline followed by intraperitoneal saline. Six weeks after treatment, the Morris water maze and Tru Scan behavioral tests and immunofluorescence staining of cerebral cortex and hippocampal neurons (by Neu-N) and microglia (by Ib1) were conducted.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Puerarin; Chronic alcohol poisoning; Neuroprotection; Microglia; Inflammatory factors. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000600515 |
| |
|
|
| LI,Bo; WEN,Shiqi; CHEN,Quan; NIU,Qibing; DONG,Fang; SUN,Wanli; DU,Junjun. |
| Abstract This study investigated the effects of puerarin (PUE) on blood lipid and inflammatory factor levels in rats with lower limb arteriosclerosis obliterans (ASO). Sixty rats were randomly divided into control, model, simvastatin, low-PUE, middle-PUE and high-dose PUE group. The animals in later 5 groups were with lower limb ASO, and the later 4 groups were given 1 mg/kg simvastatin and 5, 10 and 20 mg/kg PUE, respectively. The blood lipid and inflammatory factor levels were determined. Results showed that, the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) level in model group were significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Puerarin; Blood lipid; Inflammatory factor; Lower limb; Arteriosclerosis obliterans. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612017000500160 |
| |
|
|
|
